-
Tytuł:
-
CA.ME.LI.A. An epidemiological study on the prevalence of CArdiovascular, MEtabolic, LIver and Autoimmune diseases in Northern Italy.
-
Autorzy:
-
Bignotto M; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Dei Cas M; Clinical Biochemistry and Mass Spectrometry, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Paroni R; Clinical Biochemistry and Mass Spectrometry, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Bianco E; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Zermiani P; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Gangale MG; ASST Ovest Milanese, via Papa Giovanni Paolo II, Legnano, Milan, Italy.
Zadro V; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Maregatti M; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Piagnani A; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
Russo A; Epidemiology Unit, Agency for Health Protection of Milan, Corso Italia 19, 20122, Milan, Italy.
Baldassarre D; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy; Centro Cardiologico Monzino, IRCCS, Milan, Italy.
Folli F; Endocrinology and Metabolism, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy; ASST Santi Paolo e Carlo, University Hospital San Paolo, via A. Di Rudini', Milan, Italy. Electronic address: .
Battezzati PM; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy; ASST Santi Paolo e Carlo, University Hospital San Paolo, via A. Di Rudini', Milan, Italy.
Zuin M; Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy; ASST Santi Paolo e Carlo, University Hospital San Paolo, via A. Di Rudini', Milan, Italy. Electronic address: .
-
Źródło:
-
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 May 06; Vol. 31 (5), pp. 1416-1426. Date of Electronic Publication: 2021 Feb 11.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Publication: 2005- : Amsterdam : Elsevier
Original Publication: [Heidelberg] : Springer International, c1991-
-
MeSH Terms:
-
Autoimmune Diseases/*epidemiology
Cardiovascular Diseases/*epidemiology
Liver Diseases/*epidemiology
Metabolic Syndrome/*epidemiology
Adolescent ; Adult ; Aged ; Autoimmune Diseases/blood ; Autoimmune Diseases/diagnosis ; Biomarkers/blood ; Blood Glucose/analysis ; C-Reactive Protein/analysis ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cross-Sectional Studies ; Dyslipidemias/blood ; Dyslipidemias/epidemiology ; Female ; Glucose Metabolism Disorders/blood ; Glucose Metabolism Disorders/epidemiology ; Humans ; Italy/epidemiology ; Lipids/blood ; Liver Diseases/blood ; Liver Diseases/diagnosis ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/diagnosis ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Risk Assessment ; Risk Factors ; Sex Factors ; Time Factors ; Young Adult ; gamma-Glutamyltransferase/blood
-
Contributed Indexing:
-
Keywords: Cardiovascular risk; Diabetes; Epidemiology; Liver disease; Metabolic syndrome; Obesity; Study population
-
Substance Nomenclature:
-
0 (Biomarkers)
0 (Blood Glucose)
0 (Lipids)
9007-41-4 (C-Reactive Protein)
EC 2.3.2.2 (gamma-Glutamyltransferase)
EC 2.3.2.2 (gamma-glutamyltransferase, human)
-
Entry Date(s):
-
Date Created: 20210405 Date Completed: 20210524 Latest Revision: 20210524
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.numecd.2021.02.001
-
PMID:
-
33814235
-
Background and Aims: CA.ME.LI.A (CArdiovascular risks, MEtabolic syndrome, LIver and Autoimmune disease) is a cross-sectional, epidemiological study performed between 2009-2011 in Abbiategrasso (Milan, Italy) to estimate the prevalence of cardiovascular risk factors, metabolic syndrome, liver and autoimmune diseases in the general adult population. This report focuses on the description and presentation of baseline characteristics of the population.
Methods and Results: Citizens were randomly selected from the city electoral registers (n = 30903), yielding a sample of 2554 subjects (M = 1257, F = 1297; age, 47 ± 15 yrs; range 18-77 yrs). Men had higher prevalence of overweight or obesity (60.8% vs 41.6%; p < 0.0001) and greater thickness of visceral adipose tissue (40 ± 19 vs 27 ± 17 mm; p < 0.0001); no gender difference was found in subcutaneous adipose tissue thickness. Men also showed higher levels of serum triglycerides, γ-GT, fasting blood glucose, insulin and Homa-IR Index, while HDL, CRP, and prevalence of elevated (>5.0 mg/L) CRP were lower. Compared to normal weight men, risk-ratio (RR) of CRP elevation was 1.32 (ns) in overweight and 2.68 (p < 0.0001) in obese subjects. The corresponding figures in females were 2.68 (p < 0.0001) and 5.18 (p < 0.0001). Metabolic syndrome was more frequent in men (32.7% vs 14.5%; RR: 2.24, p < 0.0001). Interadventitia common carotid artery diameter was higher in men and increased with age and BMI.
Conclusions: The present study reports on the overall characteristics of a large population from Northern Italy. It aims to identify the associations among cardiovascular risk factors to prevent their development and progression, improve healthy lifestyle and identify subjects liable to pharmacological interventions.
Competing Interests: Declaration of competing interest The authors have nothing to disclose.
(Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
