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Tytuł:
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Causal effects of plasma lipids on the risk of atrial fibrillation: A multivariable mendelian randomization study.
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Autorzy:
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Jiang Q; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Qin D; Cardiovascular Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Yang L; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Lin Y; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhai L; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhang Y; Department of Pharmacy, The Third People's Hospital of Changzhou, Changzhou, China.
Yang G; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang K; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tong D; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Li X; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Chen Z; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Huang K; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Yu T; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Xiang X; Department of Cardiology, The Seventh People's Hospital of Changzhou, Changzhou, China.
Cui C; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Cai C; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Shi J; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Li M; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chen M; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: .
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Źródło:
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Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 May 06; Vol. 31 (5), pp. 1569-1578. Date of Electronic Publication: 2021 Feb 20.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2005- : Amsterdam : Elsevier
Original Publication: [Heidelberg] : Springer International, c1991-
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MeSH Terms:
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Polymorphism, Single Nucleotide*
Atrial Fibrillation/*blood
Atrial Fibrillation/*genetics
Lipoprotein(a)/*blood
Lipoprotein(a)/*genetics
Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Biomarkers/blood ; Case-Control Studies ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Mendelian Randomization Analysis ; Multivariate Analysis ; Phenotype ; Prognosis ; Risk Assessment ; Risk Factors ; Up-Regulation
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Contributed Indexing:
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Keywords: Atrial fibrillation; Causal effect; Mendelian randomization; Plasma lipids
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Substance Nomenclature:
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0 (Biomarkers)
0 (LPA protein, human)
0 (Lipoprotein(a))
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Entry Date(s):
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Date Created: 20210405 Date Completed: 20210524 Latest Revision: 20210524
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Update Code:
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20240105
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DOI:
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10.1016/j.numecd.2021.02.011
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PMID:
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33814236
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Background and Aims: Observational studies have suggested that plasma lipids contribute substantially to cardiovascular disease, but "cholesterol paradox" in atrial fibrillation (AF) remains. We sought to investigate the causal effects of lipid profiles on the risk of AF.
Methods and Results: Two-sample Mendelian randomization (MR) framework was implemented to examine the causality of association. Summary estimations of genetic variants associated with low density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol, total cholesterol, triglycerides, lipoprotein-a [Lp(a)], apolipoprotein A1 (ApoA 1), and apolipoprotein B (ApoB) were 81, 99, 96, 61, 30, 10, and 23 single nucleotide polymorphisms, respectively. Genetic association with AF were retrieved from a genome-wide association study that included 1,030,836 individuals. The complications for AF were predefined as cardioembolic stroke (CES) and heart failure (HF). In the multivariable MR, the odds ratios for AF per standard deviation (SD) increase were 1.030 (95% confidence interval (CI) 0.979-1.083; P = 0.257) for LDL-cholesterol, 0.986 (95% CI 0.931-1.044; P = 0.622) for HDL-cholesterol, 0.965 (95% CI 0.896-1.041; P = 0.359) for triglycerides, 1.001 (95% CI 1.000-1.003; P = 0.023) for Lp(a), 1.017 (95% CI 0.966-1.070; P = 0.518) for ApoA1, and 1.002 (95% CI 0.963-1.043; P = 0.923) for ApoB. There was no evidence that other lipid components were causally associated with AF, CES, or HF, other than for a marginal association between triglycerides and HF.
Conclusions: This MR study provides robust evidence that high Lp(a) increases the risk of AF, suggesting that interventions targeting Lp(a) may contribute to the primary prevention of AF.
Competing Interests: Declaration of competing interest All authors declare no competing interest.
(Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)