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Tytuł:
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Diabetes in pregnancy 100 years after the discovery of insulin: Hot topics and open questions to be addressed in the coming years.
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Autorzy:
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Retnakaran R; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada; Division of Endocrinology, University of Toronto, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Electronic address: .
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Źródło:
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Metabolism: clinical and experimental [Metabolism] 2021 Jun; Vol. 119, pp. 154772. Date of Electronic Publication: 2021 Apr 08.
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Typ publikacji:
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Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Publication: New York, NY : Elsevier Inc.
Original Publication: New York, Grune & Stratton.
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MeSH Terms:
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Diabetes, Gestational*/drug therapy
Diabetes, Gestational*/history
Insulin*/history
Insulin*/therapeutic use
Adult ; Child ; Child Development/physiology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; Drug Discovery/history ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Infant, Newborn ; Pregnancy ; Prenatal Exposure Delayed Effects/epidemiology ; Prenatal Exposure Delayed Effects/physiopathology ; Prenatal Exposure Delayed Effects/prevention & control
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Contributed Indexing:
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Keywords: Gestational diabetes; Postpartum; Preconception; Type 1 diabetes; Type 2 diabetes
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Substance Nomenclature:
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0 (Insulin)
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Entry Date(s):
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Date Created: 20210410 Date Completed: 20210624 Latest Revision: 20210624
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Update Code:
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20240105
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DOI:
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10.1016/j.metabol.2021.154772
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PMID:
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33838145
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By making it possible for women with diabetes to achieve their family planning goals, the discovery of insulin ushered in the field of diabetes in pregnancy. The ensuing century has witnessed tremendous advances, with clinical focus on preconception planning and maternal glycemic control making successful pregnancy an achievable goal. Currently, the global epidemic of overweight/obesity has led to maternal hyperglycemia now affecting one in every six pregnancies worldwide, prompting intense research interest. Topics of particular interest include (i) the optimal approach to diagnosing gestational diabetes mellitus (GDM); (ii) the emergence of GDM as a chronic metabolic disorder identifying future risk of non-communicable disease; (iii) the transgenerational impact of maternal glycemia as per the Developmental Origins of Health and Disease; and (iv) the application of new technology for optimizing clinical management. These topics have raised exciting questions such as (i) whether the treatment of diabetes in pregnancy can impact growth/development in childhood, (ii) whether GDM can be prevented, and (iii) whether the diagnosis of GDM could facilitate the prevention of type 2 diabetes and cardiovascular disease. Indeed, this field may be on the precipice of a golden era of new concepts and evidence to optimize the health of mother and child.
Competing Interests: Declaration of competing interest None.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
