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Tytuł:
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PET/MR imaging for the evaluation of cervical cancer during pregnancy.
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Autorzy:
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Ishiguro T; Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan. .
Nishikawa N; Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Ishii S; Department of Radiology and Nuclear Medicine, Fukushima Medical University Hospital, Fukushima, Japan.
Yoshihara K; Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Haino K; Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Yamaguchi M; Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Adachi S; Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Watanabe T; Department of Obstetrics and Gynecology, Fukushima Medical University Hospital, Fukushima, Japan.
Soeda S; Department of Obstetrics and Gynecology, Fukushima Medical University Hospital, Fukushima, Japan.
Enomoto T; Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan. .
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Źródło:
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BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2021 Apr 10; Vol. 21 (1), pp. 288. Date of Electronic Publication: 2021 Apr 10.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London : BioMed Central, [2001-
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MeSH Terms:
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Cervix Uteri/*diagnostic imaging
Magnetic Resonance Imaging/*methods
Positron-Emission Tomography/*methods
Pregnancy Complications, Neoplastic/*diagnosis
Uterine Cervical Neoplasms/*diagnosis
Adult ; Disease Progression ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Multimodal Imaging/methods ; Neoplasm Staging ; Papanicolaou Test ; Pregnancy ; Pregnancy Complications, Neoplastic/pathology ; Pregnancy Complications, Neoplastic/surgery ; Preoperative Period ; Radiopharmaceuticals/administration & dosage ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery ; Vaginal Smears
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References:
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Contributed Indexing:
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Keywords: Cervical cancer; Metastasis; PET-MRI; Pregnancy
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Substance Nomenclature:
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0 (Radiopharmaceuticals)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
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Entry Date(s):
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Date Created: 20210411 Date Completed: 20210521 Latest Revision: 20210521
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Update Code:
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20240105
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PubMed Central ID:
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PMC8037915
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DOI:
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10.1186/s12884-021-03766-w
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PMID:
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33838651
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Background: Malignancy during pregnancy is increasing, and the most common type of malignancy is uterine cervical cancer. When planning the treatment of cervical cancer, it is important to look for signs of metastasis before surgery, especially metastasis to the lymph nodes. In this report, we assessed the diagnostic value of positron emission tomography/magnetic resonance imaging (PET/MRI) for evaluating cervical cancer propagation before surgery, with a focus on pregnant women.
Case Presentation: 18 F Fluorodeoxyglucose (FDG)-PET/MRI was performed in seven pregnant cervical cancer patients (28-34 years old) at 9-18 gestational weeks. In case #5, a second PET/MRI was performed at 24 gestational weeks. Of seven FDG-PET/MRI examination series in six cases (cases #1-6), FDG-PET/MR imaging could detect cervical tumors with abnormal FDG accumulation; these tumors were confirmed with a standardized uptake value max (SUV max) titer of 4.5-16. A second PET/MRI examination in case #5 revealed the same SUV max titer as the first examination. In these six imaging series (cases #1-5), there were no signs of cancer metastasis to the parametrium and lymph nodes. However, in case #6, abnormal FDG accumulation in the left parametrial lymph nodes was also detectable. Pathological examination showed lymph node metastasis in case #6. In case #7, PET/MRI could not detect any abnormal FDG accumulation in the cervix and other sites. Cone biopsy demonstrated only micro-invasive squamous cell carcinoma. After treatment for cervical cancer, all seven patients have had no recurrence of disease within the follow-up period (2.8-5.6 years), and their children have developed appropriately.
Conclusion: PET/MRI is an effective imaging tool to evaluate cervical cancer progression in pregnancy.
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