Programmable protein circuit design.

Szczegóły
Abstrakt

Tytuł:: Programmable protein circuit design.
Autorzy:: Chen Z; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Elowitz MB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: .
Źródło:: Cell [Cell] 2021 Apr 29; Vol. 184 (9), pp. 2284-2301. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.
MeSH Terms:: Cell Physiological Phenomena*
Cellular Reprogramming*
Genetic Engineering/*methods
Proteins/*metabolism
Synthetic Biology/*methods
Animals ; Humans ; Proteins/chemistry ; Proteins/genetics
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Grant Information:: R01 EB030015 United States EB NIBIB NIH HHS; R01 MH116508 United States MH NIMH NIH HHS
Substance Nomenclature:: 0 (Proteins)
Entry Date(s):: Date Created: 20210413 Date Completed: 20211019 Latest Revision: 20231111
Update Code:: 20240104
PubMed Central ID:: PMC8087657
DOI:: 10.1016/j.cell.2021.03.007
PMID:: 33848464
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A fundamental challenge in synthetic biology is to create molecular circuits that can program complex cellular functions. Because proteins can bind, cleave, and chemically modify one another and interface directly and rapidly with endogenous pathways, they could extend the capabilities of synthetic circuits beyond what is possible with gene regulation alone. However, the very diversity that makes proteins so powerful also complicates efforts to harness them as well-controlled synthetic circuit components. Recent work has begun to address this challenge, focusing on principles such as orthogonality and composability that permit construction of diverse circuit-level functions from a limited set of engineered protein components. These approaches are now enabling the engineering of circuits that can sense, transmit, and process information; dynamically control cellular behaviors; and enable new therapeutic strategies, establishing a powerful paradigm for programming biology.
Competing Interests: Declaration of interests Z.C. and M.B.E. are inventors on patents and patent applications related to protein circuit design.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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