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Tytuł:
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Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease.
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Autorzy:
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Rusz J; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Hlavnička J; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
Novotný M; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
Tykalová T; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
Pelletier A; Department of Neurology, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Montplaisir J; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Gagnon JF; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Dušek P; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Galbiati A; Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy.
Marelli S; Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy.
Timm PC; Mayo Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN.; Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Teigen LN; Mayo Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN.; Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN.
Janzen A; Department of Neurology, Philipps University Marburg, Marburg, Germany.
Habibi M; Department of Neurology, Philipps University Marburg, Marburg, Germany.
Stefani A; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Holzknecht E; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Seppi K; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Evangelista E; National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France.
Rassu AL; National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France.
Dauvilliers Y; National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France.
Högl B; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Oertel W; Department of Neurology, Philipps University Marburg, Marburg, Germany.
St Louis EK; Mayo Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN.; Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN.; Mayo Clinic Health System Southwest Wisconsin, La Crosse, WI.
Ferini-Strambi L; Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy.
Růžička E; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Postuma RB; Department of Neurology, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Šonka K; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
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Źródło:
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Annals of neurology [Ann Neurol] 2021 Jul; Vol. 90 (1), pp. 62-75. Date of Electronic Publication: 2021 May 07.
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Typ publikacji:
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Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: New York, NY : Wiley-Liss
Original Publication: Boston, Little, Brown.
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MeSH Terms:
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Parkinson Disease/*diagnosis
REM Sleep Behavior Disorder/*diagnosis
Speech/*physiology
Aged ; Aged, 80 and over ; Biomarkers ; Disease Progression ; Europe ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/physiopathology ; Prodromal Symptoms ; REM Sleep Behavior Disorder/physiopathology
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Grant Information:
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1 UL1 RR024150-01 United States NH NIH HHS; 12546 Michal J. Fox Foundation for Parkinson's research; Canada CIHR; NU20-08-00445 Agentura Pro Zdravotnicka Vazkum Ceska Republiky; R34 AG056639 United States AG NIA NIH HHS; NV19-04-00120 Agentura Pro Zdravotnicka Vazkum Ceska Republiky; UL1 RR024150 United States RR NCRR NIH HHS; R34AG056639 United States NH NIH HHS; Charitable Hertie Foundation; ParkinsonFonds Deutschland
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Substance Nomenclature:
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0 (Biomarkers)
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Entry Date(s):
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Date Created: 20210415 Date Completed: 20210914 Latest Revision: 20210914
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Update Code:
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20240104
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PubMed Central ID:
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PMC8252762
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DOI:
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10.1002/ana.26085
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PMID:
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33856074
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Objective: This multilanguage study used simple speech recording and high-end pattern analysis to provide sensitive and reliable noninvasive biomarkers of prodromal versus manifest α-synucleinopathy in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and early-stage Parkinson disease (PD).
Methods: We performed a multicenter study across the Czech, English, German, French, and Italian languages at 7 centers in Europe and North America. A total of 448 participants (337 males), including 150 with iRBD (mean duration of iRBD across language groups 0.5-3.4 years), 149 with PD (mean duration of disease across language groups 1.7-2.5 years), and 149 healthy controls were recorded; 350 of the participants completed the 12-month follow-up. We developed a fully automated acoustic quantitative assessment approach for the 7 distinctive patterns of hypokinetic dysarthria.
Results: No differences in language that impacted clinical parkinsonian phenotypes were found. Compared with the controls, we found significant abnormalities of an overall acoustic speech severity measure via composite dysarthria index for both iRBD (p = 0.002) and PD (p < 0.001). However, only PD (p < 0.001) was perceptually distinct in a blinded subjective analysis. We found significant group differences between PD and controls for monopitch (p < 0.001), prolonged pauses (p < 0.001), and imprecise consonants (p = 0.03); only monopitch was able to differentiate iRBD patients from controls (p = 0.004). At the 12-month follow-up, a slight progression of overall acoustic speech impairment was noted for the iRBD (p = 0.04) and PD (p = 0.03) groups.
Interpretation: Automated speech analysis might provide a useful additional biomarker of parkinsonism for the assessment of disease progression and therapeutic interventions. ANN NEUROL 2021;90:62-75.
(© 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
