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Tytuł pozycji:

Estrogen receptors and their roles in the immune and respiratory systems.

Tytuł:
Estrogen receptors and their roles in the immune and respiratory systems.
Autorzy:
Millas I; UNINOVE Curso de Medicina Ringgold Standard Institution-Medical School, Sao Paulo, Brazil.
Duarte Barros M; FCMSCSP Ringgold Standard Institution-Morphology, São Paulo, Brazil.
Źródło:
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2021 Jun; Vol. 304 (6), pp. 1185-1193. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Original Publication: Hoboken, NJ : John Wiley & Sons, 2007-
MeSH Terms:
COVID-19/*immunology
Estrogen Receptor alpha/*immunology
Estrogen Receptor beta/*immunology
Immune System/*immunology
Respiratory System/*immunology
SARS-CoV-2/*immunology
Animals ; COVID-19/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Humans ; Immune System/metabolism ; Nasal Mucosa/immunology ; Nasal Mucosa/metabolism ; Respiratory System/metabolism ; SARS-CoV-2/metabolism
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Contributed Indexing:
Keywords: coronovirus infections; estrogen; estrogen receptors; immune response; respiratory system
Substance Nomenclature:
0 (ESR1 protein, human)
0 (Estrogen Receptor alpha)
0 (Estrogen Receptor beta)
Entry Date(s):
Date Created: 20210415 Date Completed: 20210608 Latest Revision: 20210816
Update Code:
20240104
DOI:
10.1002/ar.24612
PMID:
33856123
Czasopismo naukowe
Estrogen is an important hormone for health in both genders. It is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, and neural functions. The main way that estrogen acts in the cells is through estrogen receptors (ERs). The presence of specific estrogen receptors is required for estrogen to have its characteristic ubiquitous action in almost all tissues. Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) are the major isoforms of estrogen that are highly specific in humans and enable selective hormonal actions in different tissues. This article reviews some of the observed estrogen actions and effects in different tissues and cells through these specific receptors. This ubiquitous, almost ordinary hormone may reveal itself as a significant factor that helped us to better understand the complexity of the human immune system response against respiratory infections, including the COVID-19, and especially in the current state of this painful pandemic.
(© 2021 American Association for Anatomy.)

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