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Tytuł:
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The differential calibration of the HPA axis as a function of trauma versus adversity: A systematic review and p-curve meta-analyses.
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Autorzy:
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Hosseini-Kamkar N; Cognitive Development and Neuroimaging Laboratory, The Brain and Mind Institute, Western University, London, ON, Canada. Electronic address: .
Lowe C; Cognitive Development and Neuroimaging Laboratory, The Brain and Mind Institute, Western University, London, ON, Canada. Electronic address: .
Morton JB; Cognitive Development and Neuroimaging Laboratory, The Brain and Mind Institute, Western University, London, ON, Canada. Electronic address: .
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Źródło:
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Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2021 Aug; Vol. 127, pp. 54-135. Date of Electronic Publication: 2021 Apr 20.
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Typ publikacji:
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Journal Article; Meta-Analysis; Review; Systematic Review
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Język:
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English
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Imprint Name(s):
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Publication: New York Ny : Pergamon Press
Original Publication: Fayetteville, N. Y., ANKHO International Inc.
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MeSH Terms:
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Hypothalamo-Hypophyseal System*
Pituitary-Adrenal System*
Calibration ; Humans ; Hydrocortisone ; Saliva ; Stress, Psychological
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Contributed Indexing:
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Keywords: Adversity; Cortisol; HPA axis; Meta-analysis; Review; Trauma; p-curve
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Substance Nomenclature:
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WI4X0X7BPJ (Hydrocortisone)
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Entry Date(s):
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Date Created: 20210415 Date Completed: 20210803 Latest Revision: 20220531
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Update Code:
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20240104
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DOI:
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10.1016/j.neubiorev.2021.04.006
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PMID:
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33857580
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Although there is an abundance of evidence linking the function of the hypothalamic-pituitary-adrenal (HPA) axis to adverse early-life experiences, the precise nature of the association remains unclear. Some evidence suggests early-life adversity leads to cortisol hyper-reactivity, while other evidence suggests adversity leads to cortisol hypo-reactivity. Here, we distinguish between trauma and adversity, and use p-curves to interrogate the conflicting literature. In Study 1, trauma was operationalized according to DSM-5 criteria; the p-curve analysis included 68 articles and revealed that the literature reporting associations between trauma and blunted cortisol reactivity contains evidential value. Study 2 examined the relationship between adversity and cortisol reactivity. Thirty articles were included in the analysis, and p-curve demonstrated that adversity is related to heightened cortisol reactivity. These results support an inverted U-shaped function relating severity of adversity and cortisol reactivity, and underscore the importance of distinguishing between "trauma" and "adversity".
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
