Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon.

Szczegóły
Abstrakt

Tytuł:: Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon.
Autorzy:: Honkpéhèdji YJ; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.
Adegbite BR; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; Center of Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, The Netherlands.
Zinsou JF; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.
Dejon-Agobé JC; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; Center of Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, The Netherlands.
Edoa JR; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Zoleko Manego R; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
McCall M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.
Mbong Ngwese M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Lotola Mougeni F; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Mombo-Ngoma G; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Ramharter M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Kremsner PG; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; German Center for Infection Research, Tübingen, Germany.
Lell B; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Yazdanbakhsh M; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Esen M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; German Center for Infection Research, Tübingen, Germany.
Adegnika AA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.; Institut für Tropenmedizin, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.; German Center for Infection Research, Tübingen, Germany.
Źródło:: Tropical medicine & international health : TM & IH [Trop Med Int Health] 2021 Aug; Vol. 26 (8), pp. 973-981. Date of Electronic Publication: 2021 May 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Oxford : Blackwell Scientific Publications
Original Publication: Oxford, UK : Blackwell Science Ltd, c1996-
MeSH Terms:: Infant, Low Birth Weight*
Prenatal Care*
Parasitic Diseases/*epidemiology
Pregnancy Complications, Infectious/*epidemiology
Adolescent ; Adult ; Birth Weight ; Female ; Gabon/epidemiology ; Humans ; Infant, Newborn ; Male ; Parasitic Diseases/etiology ; Pregnancy ; Pregnancy Complications, Infectious/etiology ; Young Adult
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Contributed Indexing:: Keywords: Lambaréné; low birth weight; polyparasitism; pregnancy
Entry Date(s):: Date Created: 20210416 Date Completed: 20210816 Latest Revision: 20210816
Update Code:: 20240104
DOI:: 10.1111/tmi.13591
PMID:: 33860600
: Czasopismo naukowe

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Objective: To report the prevalence of polyparasitism during pregnancy in the Lambaréné region of Gabon and its association with newborn birth weight.
Method: Pregnant women in their third trimester were recruited in a prospective study between November 2011 and March 2015. Parasite infection status was assessed microscopically in stool, urine and blood samples. Maternal demographic and obstetrical characteristics and newborns anthropometric data were collected. Multivariable logistic regression was used to assess the association between low birth weight and polyparasitism.
Results: 678 of 927 pregnant women were included for analysis with mean age (SD) of 25 (6.8) years. The analysis showed that 69% (468/678) were infected with at least one parasite (Plasmodium spp., Schistosoma spp., soil-transmitted helminths, filarial infections). This comprised of 38% with monoparasitism and 31% polyparasitism. The proportion of newborn babies with a weight below 2500 g (LBW) in our study was 21% (142/678). Compared to pregnant women without infection, women with monoparasitic infection had adjusted Odds Ratio confidence interval 95% CI (aOR [95%CI]) of 1.6 [0.95-2.73], those with two parasites had aOR 95%CI of 2.63 [1.51-4.62], and those with more than two parasites had aOR of 5.08 [2.5-10.38] for delivering a newborn with low birth weight.
Conclusion: In Lambaréné, an endemic area for multiple parasite infections, there is a high prevalence of polyparasitism in pregnant women. Polyparasitism is associated with low birth weight. Therefore, there is an urgent need for active screening and treatment of parasite infections in pregnant women to assess the potential public health benefit of such interventions.
(© 2021 John Wiley & Sons Ltd.)

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