Does XIST safeguard against sex-biased human diseases?

Tytuł:: Does XIST safeguard against sex-biased human diseases?
Autorzy:: Sado T; Department of Advanced Bioscience, Graduate School of Agriculture, and Agricultural Technology and Innovation Research Institute, Kindai University, 3327-204, Nakamachi, Nara, 631-8505, Japan. Electronic address: .
Źródło:: Molecular cell [Mol Cell] 2021 Apr 15; Vol. 81 (8), pp. 1598-1600.
Typ publikacji:: Journal Article; Comment
Język:: English
Imprint Name(s):: Publication: Cambridge Ma : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1997-
MeSH Terms:: RNA, Long Noncoding*/genetics
X Chromosome Inactivation*/genetics
B-Lymphocytes ; Cell Differentiation ; Female ; Humans ; X Chromosome/genetics
Substance Nomenclature:: 0 (RNA, Long Noncoding)
Entry Date(s):: Date Created: 20210416 Date Completed: 20210429 Latest Revision: 20210429
Update Code:: 20240104
DOI:: 10.1016/j.molcel.2021.03.036
PMID:: 33861949
: Czasopismo naukowe

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Yu et al. (2021) demonstrate that a subset of X-linked immune genes is repressed on the inactive X chromosome (Xi) in a manner dependent on XIST RNA in B cells, and derepression of these genes upon XIST depletion could bias differentiation of naive B cells and be involved in etiology of female-biased autoimmune diseases.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

Comment on: Cell. 2021 Apr 1;184(7):1790-1803.e17. (PMID: 33735607)

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