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Tytuł:
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Ninjin'yoeito modulates feeding and activity under negative energy balance conditions via the NPY system.
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Autorzy:
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Zhang L; Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, Australia; St. Vincent's Clinical School, University of NSW, Sydney, Australia. Electronic address: .
Clark T; The Charles Perkins Centre, School of Life & Environmental Sciences, The University of Sydney, NSW 2006, Australia.
Gopalasingam G; Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, Australia.
Neely GG; The Charles Perkins Centre, School of Life & Environmental Sciences, The University of Sydney, NSW 2006, Australia.
Herzog H; Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, Australia; School of Medical Sciences, University of NSW, Sydney, NSW, Australia; Faculty of Medicine, University of NSW, Sydney, NSW, Australia.
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Źródło:
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Neuropeptides [Neuropeptides] 2021 Jun; Vol. 87, pp. 102149. Date of Electronic Publication: 2021 Apr 15.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: 2002- : Amsterdam : Elsevier
Original Publication: Edinburgh ; New York : Churchill Livingstone, c1980-
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MeSH Terms:
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Drugs, Chinese Herbal/*pharmacology
Energy Intake/*drug effects
Energy Metabolism/*drug effects
Feeding Behavior/*drug effects
Motor Activity/*drug effects
Neuropeptide Y/*metabolism
Peptide YY/*deficiency
Receptors, Neuropeptide Y/*deficiency
Animals ; Cross-Over Studies ; Drosophila melanogaster ; Female ; Homeostasis ; Humans ; Male ; Medicine, Kampo ; Metabolism/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Peptide YY/genetics ; Peptide YY/physiology ; Random Allocation ; Receptors, Neuropeptide Y/genetics ; Receptors, Neuropeptide Y/physiology
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Contributed Indexing:
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Keywords: Activity; Energy balance; Feeding; NPY; Ninjin'yoeito; Y4
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Substance Nomenclature:
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0 (Drugs, Chinese Herbal)
0 (Neuropeptide Y)
0 (Receptors, Neuropeptide Y)
0 (ninjin'yoeito)
106388-42-5 (Peptide YY)
55F8T1GN3X (neuropeptide Y4 receptor)
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Entry Date(s):
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Date Created: 20210421 Date Completed: 20211203 Latest Revision: 20211214
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Update Code:
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20240104
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DOI:
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10.1016/j.npep.2021.102149
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PMID:
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33882337
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The central and peripheral neuropeptide Y (NPY) system is critically involved in feeding and energy homeostasis control. Disease conditions as well as aging can lead to reduced functionality of the NPY system and boosting it represents a promising option to improve health outcomes in these situations. Here we show that Ninjin-yoeito (NYT), a Japanese kampo medicine comprising twelve herbs, and known to be effective to treat anorexia and frailty, mediates part of its action via NPY/peptide YY (PYY) related pathways. Especially under negative energy homeostasis conditions NYT is able to promote feeding and reduces activity to conserve energy. These effects are in part mediated via signalling through the NPY system since lack of Y4 receptors or PYY leading to modification in these responses highlighting the possibility for combination treatment to improve aging related conditions on energy homeostasis control.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
