Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement.

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Abstrakt

Tytuł:: Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement.
Autorzy:: Nishimoto R; Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan.; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan.; Department of Anesthesiology and Resuscitology, Okayama University Hospital, 700-8558 Okayama, Japan.
Derouiche S; Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan.; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan.; Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan.
Eto K; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan.; Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585 Okazaki, Japan.
Deveci A; Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan.; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan.; Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan.
Kashio M; Department of Physiology, Aichi Medical University, 480-1195 Nagakute, Japan.
Kimori Y; Department of Management and Information Sciences, Faculty of Environmental and Information Sciences, Fukui University of Technology, 910-8505 Fukui, Japan.
Matsuoka Y; Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 700-8558 Okayama, Japan.
Morimatsu H; Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 700-8558 Okayama, Japan.
Nabekura J; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan.; Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585 Okazaki, Japan.
Tominaga M; Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan; .; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan.; Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan.; Institute for Environmental and Gender-Specific Medicine, Juntendo University, 279-0021 Chiba, Japan.
Źródło:: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 27; Vol. 118 (17).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Washington, DC : National Academy of Sciences
MeSH Terms:: Cell Movement/*physiology
Microglia/*metabolism
TRPV Cation Channels/*metabolism
Animals ; Cells, Cultured ; Central Nervous System/metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction ; TRPV Cation Channels/physiology ; Temperature ; Transient Receptor Potential Channels/metabolism
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Contributed Indexing:: Keywords: TRP channels; TRPV4; microglia; movement
Substance Nomenclature:: 0 (TRPV Cation Channels)
0 (Transient Receptor Potential Channels)
0 (Trpv4 protein, mouse)
Entry Date(s):: Date Created: 20210423 Date Completed: 20211207 Latest Revision: 20211214
Update Code:: 20240104
PubMed Central ID:: PMC8092382
DOI:: 10.1073/pnas.2012894118
PMID:: 33888579
: Czasopismo naukowe

Microglia maintain central nervous system homeostasis by monitoring changes in their environment (resting state) and by taking protective actions to equilibrate such changes (activated state). These surveillance and protective roles both require constant movement of microglia. Interestingly, induced hypothermia can reduce microglia migration caused by ischemia, suggesting that microglia movement can be modulated by temperature. Although several ion channels and transporters are known to support microglia movement, the precise molecular mechanism that regulates temperature-dependent movement of microglia remains unclear. Some members of the transient receptor potential (TRP) channel superfamily exhibit thermosensitivity and thus are strong candidates for mediation of this phenomenon. Here, we demonstrate that mouse microglia exhibit temperature-dependent movement in vitro and in vivo that is mediated by TRPV4 channels within the physiological range of body temperature. Our findings may provide a basis for future research into the potential clinical application of temperature regulation to preserve cell function via manipulation of ion channel activity.
Competing Interests: The authors declare no competing interest.
(Copyright © 2021 the Author(s). Published by PNAS.)

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