Small Heat Shock Proteins HSP10 and HSP27 in the Left Ventricular Myocardium in Rats with Arterial Hypertension and Insulin-Dependent Diabetes Mellitus.

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Tytuł:: Small Heat Shock Proteins HSP10 and HSP27 in the Left Ventricular Myocardium in Rats with Arterial Hypertension and Insulin-Dependent Diabetes Mellitus.
Autorzy:: Sklifasovskaya AP; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Blagonravov ML; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia. .
Źródło:: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Apr; Vol. 170 (6), pp. 699-705. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
MeSH Terms:: Chaperonin 10/*metabolism
HSP27 Heat-Shock Proteins/*metabolism
Heat-Shock Proteins, Small/*metabolism
Myocardium/*metabolism
Myocytes, Cardiac/*metabolism
Pulmonary Arterial Hypertension/*metabolism
Animals ; Chaperonin 10/genetics ; HSP27 Heat-Shock Proteins/genetics ; Heat-Shock Proteins, Small/genetics ; Immunohistochemistry ; Male ; Pulmonary Arterial Hypertension/genetics ; Rats ; Rats, Inbred SHR ; Rats, Wistar ; Streptozocin
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Contributed Indexing:: Keywords: HSP10; HSP27; arterial hypertension; diabetes mellitus; small heat shock proteins
Substance Nomenclature:: 0 (Chaperonin 10)
0 (HSP27 Heat-Shock Proteins)
0 (Heat-Shock Proteins, Small)
5W494URQ81 (Streptozocin)
Entry Date(s):: Date Created: 20210424 Date Completed: 20211126 Latest Revision: 20211126
Update Code:: 20240104
DOI:: 10.1007/s10517-021-05136-0
PMID:: 33893951
: Czasopismo naukowe

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We studied the expression of small heat shock proteins HSP10 and HSP27 in left ventricular cardiomyocytes in animals with arterial hypertension, insulin-dependent diabetes mellitus, and their combination. The experiment was performed on 38-week-old male Wistar-Kyoto and 38-57-week-old SHR (spontaneously hypertensive) rats. Insulin-dependent diabetes mellitus was modeled by single parenteral injection of streptozotocin (65 mg/kg). Expression of HSP10 and HSP27 in left ventricular cardiomyocytes was evaluated by immunohistochemical assay. It was found that the content of HSP10 in the left ventricular cardiomyocytes decreased in comparison with the control in case of isolated diabetes mellitus and, on the contrary, increased in case of arterial hypertension combined with diabetes mellitus. The intensity of HSP27 expression decreased in case of 38-week arterial hypertension and a combination of arterial hypertension with diabetes mellitus. However, in case of 57-week arterial hypertension we observed an increase in the content of HSP27 in cardiomyocytes.

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