Traditional Chinese Medicine Brucea Javanica Oil Enhances the Efficacy of Anlotinib in a Mouse Model of Liver-Metastasis of Small-cell Lung Cancer.

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Abstrakt

Tytuł:: Traditional Chinese Medicine Brucea Javanica Oil Enhances the Efficacy of Anlotinib in a Mouse Model of Liver-Metastasis of Small-cell Lung Cancer.
Autorzy:: Peng S; The Third Affiliated Hospital of Anhui Medical University, Hefei, P.R. China; .; Hefei First People's Hospital, Hefei, P.R. China.
Dong W; The Third Affiliated Hospital of Anhui Medical University, Hefei, P.R. China.; Hefei First People's Hospital, Hefei, P.R. China.
Chu Q; The Third Affiliated Hospital of Anhui Medical University, Hefei, P.R. China.; Hefei First People's Hospital, Hefei, P.R. China.
Meng J; The Third Affiliated Hospital of Anhui Medical University, Hefei, P.R. China.; Hefei First People's Hospital, Hefei, P.R. China.
Yang H; The Third Affiliated Hospital of Anhui Medical University, Hefei, P.R. China.; Hefei First People's Hospital, Hefei, P.R. China.
DU Y; The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. China.
Sun YU; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, UCSD, San Diego, CA, U.S.A.
Hoffman RM; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, UCSD, San Diego, CA, U.S.A.
Źródło:: In vivo (Athens, Greece) [In Vivo] 2021 May-Jun; Vol. 35 (3), pp. 1437-1441.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2000- > : Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens : Dr. J.G. Delinassios
MeSH Terms:: Brucea*
Liver Neoplasms*/drug therapy
Lung Neoplasms*/drug therapy
Animals ; Indoles ; Medicine, Chinese Traditional ; Mice ; Mice, Nude ; Plant Oils ; Quinolines
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Contributed Indexing:: Keywords: Brucea javanica oil; SCLC; angiogenesis; anlotinib; combination therapy; efficacy; liver metastasis; nude mouse; small-cell lung cancer
Substance Nomenclature:: 0 (Indoles)
0 (Plant Oils)
0 (Quinolines)
0 (anlotinib)
Entry Date(s):: Date Created: 20210429 Date Completed: 20210618 Latest Revision: 20210629
Update Code:: 20240104
PubMed Central ID:: PMC8193324
DOI:: 10.21873/invivo.12395
PMID:: 33910820
: Czasopismo naukowe

Background/aim: Small-cell lung cancer (SCLC) is a recalcitrant disease with liver and other metastasis. The present study evaluated the efficacy of the traditional Chinese medicine Brucea javanica oil (BJO) combined with anlotinib, a multi-tyrosine kinase inhibitor with anti-angiogenic activity, on a nude-mouse model of SCLC liver metastasis.
Materials and Methods: The mouse model was established by injecting NCI-H446 cells (1×10 6 ) in Matrigel (20 μl) into the upper liver lobe. All animals were randomized and assigned to three groups: Control (n=8); anlotinib alone (n=8; 3 mg/kg, qd×14+7-day interval with two cycles, oral); anlotinib plus BJO (n=8; 3 mg/kg anlotinib qd×14+7-day interval with two cycles, orally; BJO: 1 g/kg, qd×6 weeks, orally). Body weight was determined every week. Six weeks after initial treatment, tumors were collected for analysis of angiogenesis using immunohistochemistry.
Results: The combination of anlotinib and BJO significantly inhibited growth of SCLC liver metastases and angiogenesis more than anlotinib monotherapy (p=0.043). In addition, BJO alleviated body-weight loss associated with anlotinib therapy, including general mouse condition.
Conclusion: The results of the present study indicate that the combination of anlotinib with BJO is promisingly active against liver metastases of SCLC, and has clinical potential.
(Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

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