Solid-phase optimisation for simultaneous determination of thirteen pharmaceuticals in Ethiopian water samples with HPLC-DAD detection: an initial assessment.

Szczegóły
Abstrakt

Tytuł:: Solid-phase optimisation for simultaneous determination of thirteen pharmaceuticals in Ethiopian water samples with HPLC-DAD detection: an initial assessment.
Autorzy:: Tegegne B; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag X3, Johannesburg, 2050, South Africa.; Department of Chemistry, College of Natural and Computational Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.; Department of Chemistry, College of Natural Sciences, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia.
Chandravanshi BS; Department of Chemistry, College of Natural and Computational Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Zewge F; Department of Chemistry, College of Natural and Computational Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Chimuka L; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag X3, Johannesburg, 2050, South Africa. .
Źródło:: Environmental monitoring and assessment [Environ Monit Assess] 2021 Apr 29; Vol. 193 (5), pp. 310. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 1998- : Dordrecht : Springer
Original Publication: Dordrecht, Holland ; Boston : D. Reidel Pub. Co., c1981-
MeSH Terms:: Pharmaceutical Preparations*
Water Pollutants, Chemical*/analysis
Chromatography, High Pressure Liquid ; Environmental Monitoring ; Ethiopia ; Solid Phase Extraction ; Tandem Mass Spectrometry ; Water
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Contributed Indexing:: Keywords: Ethiopia; HPLC-DAD; Pharmaceuticals; Solid-phase extraction; Water samples
Substance Nomenclature:: 0 (Pharmaceutical Preparations)
0 (Water Pollutants, Chemical)
059QF0KO0R (Water)
Entry Date(s):: Date Created: 20210429 Date Completed: 20210503 Latest Revision: 20210503
Update Code:: 20240104
DOI:: 10.1007/s10661-021-08999-y
PMID:: 33914171
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Pharmaceutical consumption is increasing worldwide as it is essential to treat and prevent health issues but they end up in the environment. However, in many African countries like Ethiopia, the status of these compounds in various environmental samples is not very well known. In this study, a simple method for the extraction and determination of thirteen pharmaceutical compounds of different therapeutic classes in water samples using solid-phase extraction and HPLC-DAD was developed. Different parameters affecting extraction were optimised and obtained as hydrophilic-lipophilic balance (HLB) extraction cartridge, water sample pH of 5, elution solvent of 2% formic acid in water with methanol (20:80%, v/v), a sample volume of 150 mL and addition of 0.5% w/v EDTA in the sample. The limits of detection and quantification of the optimised method were in the range of 0.1-0.8 µg/L and 0.2-2.6 µg/L, respectively. The relative recovery in the spiked environmental water sample was in the range of 70-117% except for amoxicillin and acetylsalicylic acid in influent wastewater. The precision for all ranged from 0.3 to 11%. The proposed method was successfully tested for the detection and quantification of different environmental water samples collected from Addis Ababa, Ethiopia. Trimethoprim, caffeine and albendazole concentrations of 7.8 (1.1), 3.2 (0.4) and 2.1 (0.1) µg/L were quantified in hospital wastewater, respectively. The concentration of norfloxacin was found to be below the limit of quantification in the same water. Trimethoprim and ciprofloxacin were also found in the sewage treatment plant influent sample at a concentration of 0.5 (0.02) and 0.3 (0.01) µg/L, respectively.

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