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Tytuł pozycji:

Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration.

Tytuł :
Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration.
Autorzy :
Abruzzese V; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Matera I; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Martinelli F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Carmosino M; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Koshal P; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Milella L; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Ostuni A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 08; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Basel, Switzerland : MDPI, [2000-
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Grant Information :
INBIOMED PROJECT (MIUR, ARS01_01081). INBIOMED PROJECT (MIUR, ARS01_01081).
Contributed Indexing :
Keywords: ABCC6; HepG2; PI3K/AKT signaling; cell migration; cytoskeleton; quercetin
Entry Date(s) :
Date Created: 20210430 Latest Revision: 20210502
Update Code :
20210506
PubMed Central ID :
PMC8069417
DOI :
10.3390/ijms22083871
PMID :
33918053
Czasopismo naukowe
Quercetin is a member of the flavonoid group of compounds, which is abundantly present in various dietary sources. It has excellent antioxidant properties and anti-inflammatory activity and is very effective as an anti-cancer agent against various types of tumors, both in vivo and in vitro. Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5'-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis. In this study, we investigated the effect of Quercetin on ABCC6 expression in HepG2 cells. ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters, poorly involved in drug resistance, whose mutations cause pseudoxanthoma elasticum, an inherited disease characterized by ectopic calcification of soft connective tissues. Recently, it has been reported that ABCC6 contributes to cytoskeleton rearrangements and HepG2 cell motility through purinergic signaling. Gene and protein expression were evaluated by quantitative Reverse-Transcription PCR (RT-qPCR) and western blot, respectively. Actin cytoskeleton dynamics was evaluated by laser confocal microscopy using fluorophore-conjugated phalloidin. Cell motility was analyzed by an in vitro wound-healing migration assay. We propose that ABCC6 expression may be controlled by the AKT pathway as part of an adaptative response to oxidative stress, which can be mitigated by the use of Quercetin-like flavonoids.
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