Asthma in the Precision Medicine Era: Biologics and Probiotics.

Szczegóły
Abstrakt

Tytuł:: Asthma in the Precision Medicine Era: Biologics and Probiotics.
Autorzy:: Chiu CJ; Graduate Institute of Clinical Medicine, School of Medicine, National Taiwan University, Taipei 100, Taiwan.
Huang MT; Graduate Institute of Clinical Medicine, School of Medicine, National Taiwan University, Taipei 100, Taiwan.; Department of Medical Research, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei 100, Taiwan.; Department of Pediatrics, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei 100, Taiwan.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 26; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 26.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Asthma/*drug therapy
Asthma/*physiopathology
Precision Medicine/*methods
Asthma/metabolism ; Biological Products/therapeutic use ; Biomarkers ; Humans ; Microbiota/physiology ; Phenotype ; Probiotics/therapeutic use ; Th2 Cells
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Grant Information:: MOST 108-2321-B-002-057-MY3 and MOST 109-2314-B-002-136-MY3 Ministry of Science and Technology, Taiwan
Contributed Indexing:: Keywords: asthma; asthma endotype; biologic therapy; microbiota; precision medicine; probiotics
Substance Nomenclature:: 0 (Biological Products)
0 (Biomarkers)
Entry Date(s):: Date Created: 20210430 Date Completed: 20210603 Latest Revision: 20230920
Update Code:: 20240104
PubMed Central ID:: PMC8123613
DOI:: 10.3390/ijms22094528
PMID:: 33926084
: Czasopismo naukowe

Pełny tekst

Asthma is a major global health issue. Over 300 million people worldwide suffer from this chronic inflammatory airway disease. Typical clinical symptoms of asthma are characterized by a recurrent wheezy cough, chest tightness, and shortness of breath. The main goals of asthma management are to alleviate asthma symptoms, reduce the risk of asthma exacerbations, and minimize long-term medicinal adverse effects. However, currently available type 2 T helper cells (Th2)-directed treatments are often ineffective due to the heterogeneity of the asthma subgroups, which manifests clinically with variable and poor treatment responses. Personalized precision therapy of asthma according to individualized clinical characteristics (phenotype) and laboratory biomarkers (endotype) is the future prospect. This mini review discusses the molecular mechanisms underlying asthma pathogenesis, including the hot sought-after topic of microbiota, add-on therapies and the potential application of probiotics in the management of asthma.

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