Chronic myeloid leukemia with a significant increase of monocytes and rare karyotype: A case report and literature review.

Szczegóły
Abstrakt

Tytuł:: Chronic myeloid leukemia with a significant increase of monocytes and rare karyotype: A case report and literature review.
Autorzy:: Zhang Y; Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008. .
Tan Q; Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008.
Cao P; Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008.
Chen C; Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008.
Chen W; Department of Gastroenterology, Changsha Central Hospital, Changsha 410004, China. .
Transliterated Title:: 单核细胞显著增加的初诊慢性粒细胞白血病伴罕见核型1例及文献复习.
Źródło:: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences [Zhong Nan Da Xue Xue Bao Yi Xue Ban] 2021 Mar 28; Vol. 46 (3), pp. 322-327.
Typ publikacji:: Case Reports; Journal Article; Review
Język:: English; Chinese
Imprint Name(s):: Original Publication: Changsha Shi : "Zhong nan da xue xue bao (yi xue ban)" bian ji bu, 2004-
MeSH Terms:: Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Monocytes*
Adult ; Humans ; Karyotype ; Karyotyping ; Male ; Translocation, Genetic
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Contributed Indexing:: Keywords: 7) (p13; chromosome translocation t(2; chronic myeloid leukemia; chronic myelomonocytic leukemia; p22)
Local Abstract: [Publisher, Chinese] 单核细胞增加的慢性粒细胞白血病临床少见，与慢性粒-单核细胞白血病难以鉴别。1例31岁男性患者，以全身疼痛起病，初步诊断为慢性粒单核细胞白血病，经融合基因和染色体等检查最终确诊为慢性粒细胞白血病。除了典型的Ph染色体外，还发现罕见的染色体易位t(2; 7)(p13; p22)。流式细胞学检测单核细胞亚群有助于鉴别诊断，融合基因与单核细胞增加的关系尚不明确。采用酪氨酸激酶抑制剂或者异基因造血干细胞移植治疗。.
Entry Date(s):: Date Created: 20210430 Date Completed: 20210503 Latest Revision: 20240321
Update Code:: 20240321
PubMed Central ID:: PMC10929936
DOI:: 10.11817/j.issn.1672-7347.2021.200273
PMID:: 33927081
: Czasopismo naukowe

Chronic myeloid leukemia with a significant increase of monocytes is rare and difficult to identify from chronic myelo-monocytic leukemia in clinic. A 31-year-old male patient with systemic pain was initially diagnosed as chronic myelo-monocytic leukemia, who was finally diagnosed as chronic myeloid leukemia by fusion gene and chromosome examination. In addition to the typical Ph chromosome, a rare chromosome translocation t(2; 7)(p13; p22) was observed. The detection of monocyte subsets by multi-parameter flow cytometry is a diagnostic marker to distinguish the above 2 diseases. The relationship between fusion genes and mononucleosis is not clear. Tyrosine kinase inhibitors or allogeneic hematopoietic stem cell transplantation can be used in the treatment for this disease.

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