Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis.

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Tytuł:: Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis.
Autorzy:: Tahtabasi M; Department of Radiology, University of Health Sciences- Mehmet Akif Inan Education and Research Hospital, Sanliurfa, Turkey. Electronic address: .
Hosbul T; Department of Medical Microbiology, Gulhane Medical Faculty, University of Health Sciences, Ankara, Turkey.
Karaman E; Department of Radiology, University of Health Sciences- Mehmet Akif Inan Education and Research Hospital, Sanliurfa, Turkey.
Akin Y; Department of Radiology, University of Health Sciences- Mehmet Akif Inan Education and Research Hospital, Sanliurfa, Turkey.
Konukoglu O; Department of Radiology, University of Health Sciences- Mehmet Akif Inan Education and Research Hospital, Sanliurfa, Turkey.
Sahiner F; Department of Medical Microbiology, Gulhane Medical Faculty, University of Health Sciences, Ankara, Turkey.
Źródło:: Clinical imaging [Clin Imaging] 2021 Nov; Vol. 79, pp. 104-109. Date of Electronic Publication: 2021 Apr 28.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: [New York, NY] : Elsevier, [c1989-
MeSH Terms:: COVID-19*/immunology
Immune Tolerance*
Female ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Spleen/diagnostic imaging ; Tomography, X-Ray Computed
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Contributed Indexing:: Keywords: COVID-19; Follow-up computed tomography; Severity score; Spleen; Splenomegaly
Entry Date(s):: Date Created: 20210501 Date Completed: 20210927 Latest Revision: 20221221
Update Code:: 20240105
PubMed Central ID:: PMC8080509
DOI:: 10.1016/j.clinimag.2021.04.035
PMID:: 33932872
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Purpose: To radiologically examine how the spleen size, which has important functions in hematological and immunological balance, is affected in COVID-19.
Methods: Between July 1 and August 31, 2020, consecutive patients diagnosed with COVID-19 were analyzed. Among these patients, those who underwent chest computed tomography (CT) examination at the time of presentation, patients with follow-up CT due to clinical deterioration were included in the study. The CTs of the patients were evaluated in terms of spleen size and volume.
Results: A total of 160 patients (88 females, 55%) were included in the study. The mean time between the initial and follow-up CT was 7.2 ± 2.8 days. The splenic volume (244.3 ± 136.7 vs. 303.5 ± 156.3 cm 3 ) and splenic index (421.2 ± 235.5 vs. 523.2 ± 269.4 cm 3 ) values were significantly higher in the follow-up CT compared to the initial CT (p < 0.001). The increase in the splenic volume and splenic index values was 59.2 ± 52.4 cm 3 and 101.9 ± 90.3 cm 3 (p < 0.001), respectively. The COVID-19 severity score was significantly higher in the follow-up CT compared to the initial CT (3.7 ± 4.2 vs. 12.5 ± 5.7, respectively; p < 0.001). The spleen width measured separately on the initial and follow-up CTs showed a highest positive correlation (r = 0.982, p < 0.001).
Conclusion: Our study indicates that spleen size increases slightly-moderately in the first stages of the infection, and this increase is correlated with the COVID-19 severity score calculated on the chest CT data, and in this respect, it is similar to infections presenting with cytokine storm.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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