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Tytuł:
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Chronic exposure of zearalenone inhibits antioxidant defense and results in aging-related defects associated with DAF-16/FOXO in Caenorhabditis elegans.
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Autorzy:
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Huang CW; Institute of Food Safety and Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei, 100, Taiwan.
Liao WR; Institute of Food Safety and Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei, 100, Taiwan.
How CM; Department of Bioenvironmental Systems Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 106, Taiwan.
Yen PL; Department of Bioenvironmental Systems Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 106, Taiwan.
Wei CC; Institute of Food Safety and Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei, 100, Taiwan; Department of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei, 100, Taiwan. Electronic address: .
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Źródło:
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Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Sep 15; Vol. 285, pp. 117233. Date of Electronic Publication: 2021 Apr 25.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
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MeSH Terms:
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Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Zearalenone*
Aging ; Animals ; Antioxidants ; Caenorhabditis elegans/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Oxidative Stress
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Contributed Indexing:
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Keywords: Aging; Antioxidant defense; Caenorhabditis elegans; DAF-16/FOXO; Zearalenone
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Substance Nomenclature:
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0 (Antioxidants)
0 (Caenorhabditis elegans Proteins)
0 (Forkhead Transcription Factors)
0 (daf-16 protein, C elegans)
5W827M159J (Zearalenone)
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Entry Date(s):
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Date Created: 20210503 Date Completed: 20210811 Latest Revision: 20220531
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Update Code:
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20240104
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DOI:
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10.1016/j.envpol.2021.117233
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PMID:
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33940230
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Zearalenone (ZEN), a mycotoxin with endocrine disruptive activity and oxidative stress generating ability, has been a worldwide environmental concern for its prevalence and persistency. However, the long-term effect of ZEN on aging process is not fully elucidated. Thus, the present study applied the Caenorhabditis elegans model to investigate the aging-related toxic effect and possible underlying mechanisms under prolonged and chronic ZEN exposure. Our results showed that locomotive behaviors significantly decreased in ZEN (0.3, 1.25, 5, 10, 50 μM) treated C. elegans. In addition, lifespan and aging markers including pharyngeal pumping and lipofuscin were also adversely affected by ZEN (50 μM). Furthermore, ZEN (50 μM) increased ROS level and downregulated antioxidant genes resulted from inhibition of nuclear DAF-16 translocation in aged C. elegans, which was further confirmed by more significant aging-related defects observed in ZEN treated daf-16 mutant. In conclusion, our findings suggest that the aging process and aging-related decline were induced by long-term exposure of ZEN in C. elegans, which is associated with oxidative stress, inhibition of antioxidant defense, and transcription factor DAF-16/FOXO.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
