Circ&#95;0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R. - OpacWWW

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Tytuł:: Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R.
Autorzy:: Xu Y; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Li X; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Li H; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhong L; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Lin Y; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Xie J; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zheng D; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Źródło:: Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Jun; Vol. 25 (11), pp. 4912-4921. Date of Electronic Publication: 2021 May 04.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Bucharest : "Carol Davila" University Press, 2000-
MeSH Terms:: Acute Kidney Injury/*pathology
Hypoxia/*physiopathology
Kidney Tubules, Proximal/*pathology
MicroRNAs/*genetics
Oxygen/*metabolism
RNA, Circular/*genetics
Receptors, Interleukin-6/*metabolism
Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Apoptosis ; Cell Proliferation ; Cells, Cultured ; Gene Expression Regulation ; Humans ; Kidney Tubules, Proximal/metabolism ; Receptors, Interleukin-6/genetics
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Contributed Indexing:: Keywords: Circ_0023404; Hypoxia/Reoxygenation; IL-6R; acute kidney injury; miR-136
Substance Nomenclature:: 0 (MIRN136 microRNA, human)
0 (MicroRNAs)
0 (RNA, Circular)
0 (Receptors, Interleukin-6)
S88TT14065 (Oxygen)
Entry Date(s):: Date Created: 20210504 Date Completed: 20210930 Latest Revision: 20210930
Update Code:: 20240104
PubMed Central ID:: PMC8178261
DOI:: 10.1111/jcmm.15986
PMID:: 33942982
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The significance of circular RNAs (circRNAs) is reported in various kidney diseases including acute kidney injury (AKI). Specific circRNAs have the capacity to function as novel indicators of AKI. Circ_0023404 exhibits an important role in several diseases. Nevertheless, the detailed biological role of circ_0023404 in AKI remains poorly known. The present study aimed to investigate the effect of circ_0023404 on renal ischaemia/reperfusion (I/R) injury in vitro. Here, we evaluated the function of circ_0023404 in HK-2 cells in response to hypoxia/reoxygenation (H/R). We established a cell AKI model induced by H/R in HK-2 cells. We found circ_0023404 was significantly increased in AKI. Then, we found loss of circ_0023404 increased cell growth, repressed apoptosis, reduced inflammatory factors secretion and oxidative stress generation in vitro. Besides, circ_0023404 sponged miR-136. miR-136 overturned the effects of circ_0023404 on HK-2 cell injury. We assumed IL-6 receptor (IL-6R) as a target of miR-136 and IL-6R was activated by circ_0023404 via sponging miR-136. In conclusion, we revealed circ_0023404 contributed to HK-2 cells injury stimulated by H/R via sponging miR-136 and activating IL-6R.
(© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)

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Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R.