-
Tytuł:
-
Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage.
-
Autorzy:
-
Ahn SY; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea; Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul 06351, Republic of Korea.
Jie H; Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Jung WB; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 86364, Republic of Korea; Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Jeong JH; Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Ko S; Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Im GH; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 86364, Republic of Korea.
Park WS; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea; Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul 06351, Republic of Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea.
Lee JH; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 86364, Republic of Korea; Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea. Electronic address: .
Chang YS; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea; Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul 06351, Republic of Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea. Electronic address: .
Chung S; Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Electronic address: .
-
Źródło:
-
Experimental neurology [Exp Neurol] 2021 Aug; Vol. 342, pp. 113736. Date of Electronic Publication: 2021 May 01.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Orlando Fl : Academic Press
Original Publication: New York.
-
MeSH Terms:
-
Cerebral Cortex/*physiology
Cerebral Intraventricular Hemorrhage/*therapy
Cognitive Dysfunction/*therapy
Mesenchymal Stem Cell Transplantation/*methods
Neuronal Plasticity/*physiology
Thalamus/*physiology
Animals ; Animals, Newborn ; Cells, Cultured ; Cerebral Cortex/diagnostic imaging ; Cerebral Intraventricular Hemorrhage/diagnostic imaging ; Cerebral Intraventricular Hemorrhage/physiopathology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/physiopathology ; Excitatory Postsynaptic Potentials/physiology ; Humans ; Inhibitory Postsynaptic Potentials/physiology ; Magnetic Resonance Imaging/methods ; Male ; Rats ; Rats, Sprague-Dawley ; Thalamus/diagnostic imaging
-
Contributed Indexing:
-
Keywords: Barrel cortex; Functional MRI (fMRI); Intraventricular hemorrhage; Mesenchymal stem cell; Sensory-guided decision making; Thalamocortical input
-
Entry Date(s):
-
Date Created: 20210504 Date Completed: 20211011 Latest Revision: 20211011
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.expneurol.2021.113736
-
PMID:
-
33945790
-
Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
