Drug Release from Thermo-Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants.

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Abstrakt

Tytuł:: Drug Release from Thermo-Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants.
Autorzy:: Choi H; Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cµ), Department of Chemistry and Biology, School of Science and Technology, University of Siegen, Adolf-Reichwein-Str. 2, Siegen, 57076, Germany.
Schulte A; Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cµ), Department of Chemistry and Biology, School of Science and Technology, University of Siegen, Adolf-Reichwein-Str. 2, Siegen, 57076, Germany.
Müller M; Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cµ), Department of Chemistry and Biology, School of Science and Technology, University of Siegen, Adolf-Reichwein-Str. 2, Siegen, 57076, Germany.
Park M; Seoul National University Hospital Biomedical Research Institute, Seoul, 03080, Republic of Korea.
Jo S; Department of Orthopaedic Surgery, School of Medicine, Chosun University, 365 Pilmundaero, Gwangju, 61453, Republic of Korea.
Schönherr H; Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cµ), Department of Chemistry and Biology, School of Science and Technology, University of Siegen, Adolf-Reichwein-Str. 2, Siegen, 57076, Germany.
Źródło:: Advanced healthcare materials [Adv Healthc Mater] 2021 Jun; Vol. 10 (11), pp. e2100069. Date of Electronic Publication: 2021 May 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Weinheim : Wiley-VCH, 2012-
MeSH Terms:: Polymers*
Titanium*
Biofilms ; Drug Liberation ; Methacrylates
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Contributed Indexing:: Keywords: antibiotic release; bacterial biofilms; poly(di(ethylene glycol) methyl ether methacrylate); thermo-responsive polymer brushes; titanium implants
Substance Nomenclature:: 0 (Methacrylates)
0 (Polymers)
D1JT611TNE (Titanium)
Entry Date(s):: Date Created: 20210505 Date Completed: 20210622 Latest Revision: 20210622
Update Code:: 20240104
DOI:: 10.1002/adhm.202100069
PMID:: 33951320
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Despite decades of biomedical advances, the colonization of implant devices with bacterial biofilms is still a leading cause of implant failure. Clearly, new strategies and materials that suppress both initial and later stage bacterial colonization are required in this context. Ideal would be the implementation of a bactericidal functionality in the implants that is temporally and spatially triggered in an autonomous fashion at the infection site. Herein, the fabrication and validation of functional titanium-based implants with triggered antibiotic release function afforded via an intelligent polymer coating is reported. In particular, thermo-responsive poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) brushes on titanium implants synthesized via a surface-initiated atom transfer radical polymerization with activators regenerated through the electron transfer technique (ARGET ATRP) allows for a controlled and thermally triggered release of the antibiotic levofloxacin at the wound site. Antibiotic loaded brushes are investigated as a function of thickness, loading capacity for antibiotics, and temperature. At temperatures of the infection site >37 °C the lower critical solution temperature behavior of the brushes afforded the triggered release. Hence, in addition to the known antifouling effects, the PDEGMA coating ensured enhanced bactericidal effects, as demonstrated in initial in vivo tests with rodents infected with Staphylococcus aureus.
(© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.)

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