-
Tytuł:
-
Pretreatment MRI in Primary Rectal Cancer as a Predictor for Oncological Outcomes After Surgery for Local Recurrence.
-
Autorzy:
-
Elliot AH; Department of Molecular Medicine and Surgery, Karolinska Institutet, Division of Coloproctology, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden; .
Othman BN; Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden.
Suzuki C; Department of Molecular Medicine and Surgery, Karolinska Institutet, Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden.
Blomqvist L; Department of Molecular Medicine and Surgery, Karolinska Institutet, Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden.
Martling A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Division of Coloproctology, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
Johansson H; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Glimelius B; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Nilsson PJ; Department of Molecular Medicine and Surgery, Karolinska Institutet, Division of Coloproctology, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
Iversen H; Department of Molecular Medicine and Surgery, Karolinska Institutet, Division of Coloproctology, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
-
Źródło:
-
Anticancer research [Anticancer Res] 2021 May; Vol. 41 (5), pp. 2459-2465.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens, Greece : Potamitis Press
-
MeSH Terms:
-
Magnetic Resonance Angiography*
Neoplasm Recurrence, Local/*surgery
Rectal Neoplasms/*surgery
Adult ; Aged ; Aged, 80 and over ; Chemoradiotherapy/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/radiotherapy ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy ; Treatment Outcome
-
Contributed Indexing:
-
Keywords: MRI; Rectal cancer; local recurrence; oncological outcome; preoperative treatment
-
Entry Date(s):
-
Date Created: 20210506 Date Completed: 20210513 Latest Revision: 20210513
-
Update Code:
-
20240104
-
DOI:
-
10.21873/anticanres.15021
-
PMID:
-
33952471
-
Background/aim: For patients with locally recurrent rectal cancer (LRRC) extensive surgery is often the only curative option and patient selection is crucial. This study aimed to investigate whether magnetic resonance imaging (MRI) characteristics of the primary tumour can predict oncological outcome after surgery for locally recurrent rectal cancer (LRRC).
Patients and Methods: All patients undergoing surgery for LRRC with a curative intent at the Karolinska University Hospital 2003-2013 were included. MRI examinations of the primary tumour were re-evaluated.
Results: In total, 54 patients were included. A tumour volume decrease of <70% after preoperative radiotherapy or chemoradiotherapy (C)RT for the primary tumour was correlated with a lower proportion of R0 resection of the LRRC (OR=0.07, 95% CI=0.01-0.84). No association between MRI characteristics of the primary tumour and prognosis after LRRC surgery was found.
Conclusion: Long-term outcomes after surgery for LRRC were not significantly associated with MRI characteristics of the index tumour. However, factors associated with increased risk of R1 resection of LRRC were identified.
(Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
