PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.

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Tytuł:: PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.
Autorzy:: He Y; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Huang C; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Cai K; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Liu P; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Chen X; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xu YI; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Ming Z; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410008, China.
Liu Q; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xie Q; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xia X; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410008, China.
Sun Y; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Luo J; Department of General Surgery and the Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China.
Wei R; Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Źródło:: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Jul 05; Vol. 53 (7), pp. 893-902.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2022- : Shanghai : China Science Publishing & Media Ltd.
Original Publication: Shanghai : Shanghai Scientific and Technical Publishers, 2004-
MeSH Terms:: Cell Movement*/drug effects
Cell Movement*/radiation effects
Cell Proliferation*/drug effects
Cell Proliferation*/radiation effects
Chemoradiotherapy*
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/radiation effects
Radiation Tolerance*/drug effects
Radiation Tolerance*/radiation effects
Tongue Neoplasms*/genetics
Tongue Neoplasms*/metabolism
Tongue Neoplasms*/pathology
Tongue Neoplasms*/therapy
Cisplatin/*pharmacology
DNA Repair Enzymes/*metabolism
Nuclear Proteins/*metabolism
RNA Splicing Factors/*metabolism
Animals ; Cell Line, Tumor ; DNA Repair Enzymes/genetics ; Female ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Nuclear Proteins/genetics ; RNA Splicing Factors/genetics ; Radiation, Ionizing ; Xenograft Model Antitumor Assays
Grant Information:: Nos. 81974469 and 81672635 the China National Natural Science Foundation; No.2020zzts862 the Postgraduate Independent Exploration and Innovation Project of Central South University of China; No. 2018SK21214 Hunan Provincial Key Program for Research and Development
Contributed Indexing:: Keywords: PRPF19; chemoradiotherapy resistance; recurrence; tongue cancer
Substance Nomenclature:: 0 (Neoplasm Proteins)
0 (Nuclear Proteins)
0 (RNA Splicing Factors)
EC 6.5.1.- (DNA Repair Enzymes)
EC 6.5.1.- (PRPF19 protein, human)
Q20Q21Q62J (Cisplatin)
Entry Date(s):: Date Created: 20210506 Date Completed: 20210805 Latest Revision: 20210805
Update Code:: 20240104
DOI:: 10.1093/abbs/gmab059
PMID:: 33954334
: Czasopismo naukowe

Pre-mRNA processing factor 19 (PRPF19) is a multifaceted protein and participates in DNA damage response and pre-mRNA processing. The role of PRPF19 in cancer is unclear. Here, we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis. Overexpression of PRPF19 promotes while knockdown of PRPF19 inhibits tongue cancer cell migration, proliferation, and tumor growth. Overexpression of PRPF19 increases the resistance of tongue cancer cells to radiation and cisplatin treatment. Furthermore, PRPF19 regulates the expression of solute carrier family 40 member 1 (SLC40A1) and mono-ADP ribosylhydrolase 2 (MACROD2), knockdown of SLC40A1 or MACROD2 decreases the sensitivity of tongue cancer cells to radiation and cisplatin treatment. Thus, our results establish a key role of PRPF19 in tongue cancer growth and chemoradiotherapy resistance, targeting PRPF19 would be an effective therapeutic strategy for tongue cancer, especially for those resistant to chemoradiotherapy.
(© The Author(s) 2021. Published by Oxford University Press on behalf of the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

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