Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3.

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Abstrakt

Tytuł:: Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3.
Autorzy:: Park WY; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.; Basic Research Laboratory for Comorbidity Research and Comorbidity Research Institute, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Park J; Basic Research Laboratory for Comorbidity Research and Comorbidity Research Institute, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Ahn KS; Basic Research Laboratory for Comorbidity Research and Comorbidity Research Institute, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Kwak HJ; Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Republic of Korea.
Um JY; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.; Basic Research Laboratory for Comorbidity Research and Comorbidity Research Institute, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Źródło:: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jun; Vol. 35 (6), pp. e21548.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley
Original Publication: [Bethesda, Md.] : The Federation, [c1987-
MeSH Terms:: Mitochondrial Dynamics*
Adipocytes, Beige/*physiology
Adipose Tissue, White/*physiology
Ellagic Acid/*pharmacology
Gene Expression Regulation/*drug effects
Sirtuin 3/*metabolism
Adipocytes, Beige/cytology ; Adipocytes, Beige/drug effects ; Adipose Tissue, White/cytology ; Adipose Tissue, White/drug effects ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Sirtuin 3/genetics ; Thermogenesis
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Contributed Indexing:: Keywords: beige remodeling; ellagic acid; mitochondrial fission; sirtuin-3; thermogenesis
Substance Nomenclature:: 0 (Sirt3 protein, mouse)
19YRN3ZS9P (Ellagic Acid)
EC 3.5.1.- (Sirtuin 3)
Entry Date(s):: Date Created: 20210506 Date Completed: 20210719 Latest Revision: 20210719
Update Code:: 20240104
DOI:: 10.1096/fj.202002491R
PMID:: 33956354
: Czasopismo naukowe

To determine whether ellagic acid (EA) induces the "beige remodeling" of white adipose tissue (WAT), we treated cold-exposed mice and mouse stromal vascular fraction (SVF) cells with EA, a phytochemical abundant in fruits and vegetables, in particular berries. We then investigated the mechanism of EA in beige remodeling with a particular focus on DRP1-mediated mitochondrial fission and SIRT3. EA induced the trans-differentiation of white adipocytes to beige adipocytes by promoting the expression of UCP1 and other brown and beige adipocytes/fat factors (PRDM16, UCP1, PGC1α, CD137, and TBX1) and mitochondrial dynamics-related factors (SIRT3, NRF1, CPT1β, DRP1, and FIS1) in 3T3-L1/SVF cells, and these were confirmed in the inguinal WAT of a cold-exposed mouse model. The browning effect of EA was abolished by a potent DRP1 inhibitor Mdivi-1 or SIRT3 knockdown, suggesting that EA induces beige remodeling of WAT by regulating the mitochondrial dynamics and SIRT3.
(© 2021 Federation of American Societies for Experimental Biology.)

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