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Tytuł:
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Interplay between SOX9 transcription factor and microRNAs in cancer.
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Autorzy:
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Ashrafizadeh M; Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956, Istanbul, Turkey; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul 34956, Turkey.
Zarrabi A; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul 34956, Turkey.
Orouei S; Department of Genetics, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Zabolian A; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Saleki H; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Azami N; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Bejandi AK; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Mirzaei S; Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Janaghard MN; Nursing and Midwifery Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
Hushmandi K; Department of Food Hygiene and Quality Control, Division of Epidemiology & Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Nabavi N; Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H3Z6, Canada.
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Kumar AP; Cancer Science Institute of Singapore and Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Makvandi P; Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.
Samarghandian S; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: .
Khan H; Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan. Electronic address: .
Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa. Electronic address: .
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Źródło:
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International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 31; Vol. 183, pp. 681-694. Date of Electronic Publication: 2021 May 03.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
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MeSH Terms:
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MicroRNAs/*metabolism
Neoplasms/*metabolism
SOX9 Transcription Factor/*metabolism
Animals ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; RNA, Circular/genetics ; RNA, Circular/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; SOX9 Transcription Factor/genetics ; Signal Transduction
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Contributed Indexing:
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Keywords: Cancer; Circular RNA; Long non-coding RNA; MicroRNA; SOX9; Transcription factor
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Substance Nomenclature:
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0 (MicroRNAs)
0 (RNA, Circular)
0 (RNA, Long Noncoding)
0 (SOX9 Transcription Factor)
0 (SOX9 protein, human)
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Entry Date(s):
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Date Created: 20210506 Date Completed: 20210726 Latest Revision: 20210726
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Update Code:
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20240104
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DOI:
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10.1016/j.ijbiomac.2021.04.185
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PMID:
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33957202
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SOX transcription factors are critical regulators of development, homeostasis and disease progression and their dysregulation is a common finding in various cancers. SOX9 belongs to SOXE family located on chromosome 17. MicroRNAs (miRNAs) possess the capacity of regulating different transcription factors in cancer cells by binding to 3'-UTR. Since miRNAs can affect differentiation, migration, proliferation and other physiological mechanisms, disturbances in their expression have been associated with cancer development. In this review, we evaluate the relationship between miRNAs and SOX9 in different cancers to reveal how this interaction can affect proliferation, metastasis and therapy response of cancer cells. The tumor-suppressor miRNAs can decrease the expression of SOX9 by binding to the 3'-UTR of mRNAs. Furthermore, the expression of downstream targets of SOX9, such as c-Myc, Wnt, PI3K/Akt can be affected by miRNAs. It is noteworthy that other non-coding RNAs including lncRNAs and circRNAs regulate miRNA/SOX9 expression to promote/inhibit cancer progression and malignancy. The pre-clinical findings can be applied as biomarkers for diagnosis and prognosis of cancer patients.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
