Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer.

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Tytuł:: Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer.
Autorzy:: Liao R; Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.
Ma QZ; Department of Thoracic Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan P.R. China.
Zhou CY; Department of Radiation Oncology, The First Affiliated Hospital, College of Medical, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.
Li JJ; Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.
Weng NN; Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.
Yang Y; Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.
Zhu Q; Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.
Źródło:: Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 1676-1688.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin : Landes Bioscience
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Gene Regulatory Networks*
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
ADAM Proteins/genetics ; Cell Death ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; Gene Knockdown Techniques ; Genes, Neoplasm ; Humans ; Membrane Proteins/genetics ; Prognosis ; Reproducibility of Results ; Signal Transduction/genetics
References:: Nat Commun. 2015 Jan 28;6:6175. (PMID: 25629724)
Hum Exp Toxicol. 2015 Nov;34(11):1053-72. (PMID: 25585999)
Nat Med. 2015 Aug;21(8):938-945. (PMID: 26193342)
World J Gastroenterol. 2016 Apr 7;22(13):3573-80. (PMID: 27053849)
Stem Cell Reports. 2018 Mar 13;10(3):1115-1130. (PMID: 29429960)
Transl Res. 2015 Dec;166(6):602-13. (PMID: 26024798)
Oncogene. 2010 Jul 1;29(26):3758-69. (PMID: 20453887)
J Neuropathol Exp Neurol. 2006 May;65(5):516-27. (PMID: 16772875)
J Exp Clin Cancer Res. 2019 Jul 17;38(1):314. (PMID: 31315643)
Cell Biol Int. 2013 Jan;37(1):47-53. (PMID: 23319321)
Ann Oncol. 2017 May 1;28(5):1023-1031. (PMID: 28453697)
Cell. 2011 Mar 4;144(5):646-74. (PMID: 21376230)
EMBO Mol Med. 2014 Feb;6(2):278-94. (PMID: 24375628)
Cells. 2020 May 13;9(5):. (PMID: 32413966)
Science. 2006 Sep 29;313(5795):1960-4. (PMID: 17008531)
Sci Rep. 2015 Mar 20;5:9360. (PMID: 25791293)
Nat Rev Cancer. 2019 Jul;19(7):392-404. (PMID: 31209264)
Med Oncol. 2018 Jan 31;35(3):25. (PMID: 29388007)
Nature. 2014 Nov 27;515(7528):563-7. (PMID: 25428504)
Cancer. 2002 May 1;94(9):2511-6. (PMID: 12015777)
Cells. 2020 May 24;9(5):. (PMID: 32456316)
Neuro Oncol. 2015 Nov;17(11):1474-85. (PMID: 25825051)
Nat Rev Drug Discov. 2020 Mar;19(3):169-184. (PMID: 31492944)
Int J Cancer. 2018 Feb 15;142(4):779-791. (PMID: 28986926)
BMC Cancer. 2014 Aug 07;14:568. (PMID: 25098630)
Cancer Res. 2011 Sep 1;71(17):5670-7. (PMID: 21846824)
Clin Oncol (R Coll Radiol). 2017 Jul;29(7):459-465. (PMID: 28341242)
Contributed Indexing:: Keywords: ADAM8; Colorectal cancer (CRC); TILs; TIMER; cibersort; weighted gene co-expression network analysis (WGCNA)
Substance Nomenclature:: 0 (Biomarkers, Tumor)
0 (Membrane Proteins)
EC 3.4.24.- (ADAM Proteins)
EC 3.4.24.- (ADAM8 protein, human)
Entry Date(s):: Date Created: 20210507 Date Completed: 20211110 Latest Revision: 20220204
Update Code:: 20240104
PubMed Central ID:: PMC8806250
DOI:: 10.1080/21655979.2021.1921551
PMID:: 33960283
: Czasopismo naukowe

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Colorectal cancer (CRC) is one of the most common tumors, ranking second in the global cause of death from cancer. The prognosis of advanced patients is still very poor. In this study, hub modules with the highest association with tumor-infiltrating immune cells were identified by weighted gene co-expression network analysis based on CRC expression data from the Gene Expression Omnibus database. Next, three hub genes (ADAM8, IL-1A, VAV3) related to infiltrating immune cells were identified by co-expression network and prognostic analysis. After analysis and verification of the TIMER database, ADAM8 was selected as a prognostic biomarker. Finally, the result of functional test showed that ADAM8 gene expression down-regulation partially reversed the immune tolerance of CRC cells to TILs. By bioinformatics analysis methods and the experimental techniques, we identified ADAM8 as a prognostic biomarker and clinical therapeutic target related to tumor-infiltrating immune cells in CRC.

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