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Tytuł:
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A strategy of utilizing Cu -mediating interaction to prepare magnetic imprinted polymers for the selective detection of celastrol in traditional Chinese medicines.
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Autorzy:
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Li F; College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Li X; College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Su J; School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, 250100, China.
Li Y; College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China; National Demonstration Center for Experimental Chemistry Education (Nankai University), Tianjin, 300071, China.
He X; College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Chen L; College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. Electronic address: .
Zhang Y; College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116011, China.
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Źródło:
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Talanta [Talanta] 2021 Aug 15; Vol. 231, pp. 122339. Date of Electronic Publication: 2021 Mar 24.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Oxford : Pergamon Press
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MeSH Terms:
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Molecular Imprinting*
Nanotubes, Carbon*
Adsorption ; China ; Magnetic Phenomena ; Pentacyclic Triterpenes ; Polymers
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Contributed Indexing:
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Keywords: Celastrol; Cu(2+) coordination; Magnetic carbon nanotubes; Molecularly imprinted polymers; Synergistic imprinting; Traditional Chinese medicines
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Substance Nomenclature:
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0 (Nanotubes, Carbon)
0 (Pentacyclic Triterpenes)
0 (Polymers)
L8GG98663L (celastrol)
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Entry Date(s):
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Date Created: 20210509 Date Completed: 20210524 Latest Revision: 20210524
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Update Code:
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20240105
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DOI:
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10.1016/j.talanta.2021.122339
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PMID:
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33965017
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In this work, a novel strategy to prepare molecularly imprinted polymers (MIPs) functionalized magnetic carbon nanotubes (MCNTs) via a facile sol-gel polymerization by adopting Cu 2+ -mediating interaction was presented for selective recognition of celastrol (Cel), in the traditional Chinese medicines (TCM). Firstly, template Cel, 3-aminopropyltriethoxysilane (APTES) as monomer and Cu 2+ (co-monomer) were mixed to form a self-assembled pre-complex, in which Cu 2+ could coordinate with Cel. Meanwhile, APTES plays a role of bridge between APTES and Cel. Secondly, carboxyl modified MCNTs as substrate was added into the pre-complex solution. After that, a multi-step sol-gel polymerization process was occurred in the presence of tetraethylorthosilicate as cross-linker and acetic acid as catalyst. Finally, MIPs layer was formed on the surface of the MCNTs (Cel-MIPs@MCNTs) after the removal of template with methanol/acetic. The morphology and structure of Cel-MIPs@MCNTs was investigated by various characterization techniques. The adsorption performance of Cel-MIPs@MCNTs to Cel was illustrated by kinetic, isothermal and selective binding experiments. The results displayed that the Cel-MIPs@MCNTs possessed fast kinetic equilibrium time (40 s), high adsorption capacity (13.35 μg mg -1 ), good imprinting factor of 3.41, and high magnetic responsivity (44.38 emu·g -1 ), which can be used as an ideal adsorbent for rapid isolation and enrichment of target analytes. A selective and sensitive method based on Cel-MIPs@MCNTs coupling with HPLC was developed for Cel determination including a wide linear range (0.15-200 μg mL -1 ) with correlation coefficient of 0.9998, a low limit of detection (0.05 μg mL -1 ). Furthermore, the applicability of Cel-MIPs@MCNTs was demonstrated to isolate and determine Cel in TCM samples with satisfactory recoveries ranged from 84.47% to 91.5% (RSD<5.35%). The results revealed that Cel-MIPs@MCNTs offer great potential as an adsorbent for selective and efficient isolation of Cel from complex TCM samples.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
