The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics.

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Tytuł:: The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics.
Autorzy:: Wu PJ; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Wang CH; Department of Medicine, National Taiwan University, Taipei, Taiwan.
Hsieh MH; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.
Lee CY; Department of Obstetrics and Gynecology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.; Department of Nursing, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan.
Wang PH; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Lin CW; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.
Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Lee MS; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Źródło:: International journal of medical sciences [Int J Med Sci] 2021 Apr 22; Vol. 18 (11), pp. 2457-2465. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Typ publikacji:: Journal Article; Observational Study
Język:: English
Imprint Name(s):: Original Publication: [Australia] : Ivyspring International Publisher, c2004-
MeSH Terms:: Adenocarcinoma/*genetics
Aurora Kinase A/*genetics
Neoplasm Recurrence, Local/*epidemiology
Uterine Cervical Neoplasms/*genetics
Uterine Cervical Dysplasia/*genetics
Adenocarcinoma/diagnosis ; Adenocarcinoma/mortality ; Adenocarcinoma/therapy ; Adult ; Age Distribution ; Aged ; Cervix Uteri/pathology ; Disease Progression ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/genetics ; Neoplasm Staging ; Polymorphism, Single Nucleotide ; Survival Rate ; Taiwan/epidemiology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/therapy ; Uterine Cervical Dysplasia/diagnosis ; Uterine Cervical Dysplasia/mortality ; Uterine Cervical Dysplasia/therapy
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Contributed Indexing:: Keywords: Aurora kinase A; pelvic lymph node metastasis; single nucleotide polymorphisms; uterine cervical cancer
Substance Nomenclature:: EC 2.7.11.1 (AURKA protein, human)
EC 2.7.11.1 (Aurora Kinase A)
Entry Date(s):: Date Created: 20210510 Date Completed: 20211129 Latest Revision: 20221207
Update Code:: 20240105
PubMed Central ID:: PMC8100634
DOI:: 10.7150/ijms.58516
PMID:: 33967624
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The aims of this study were to explore the involvement of Aurora kinase A (AURKA) gene single nucleotide polymorphisms (SNPs) in uterine cervical cancer that has not yet been investigated. One hundred and six patients with cervical invasive cancer and 94 patients with precancerous lesions, and 302 Taiwanese female individuals were included. AURKA SNPs rs2273535, rs6024836, rs2064863 and rs1047972 were analyzed for genotypic distributions using real-time polymerase chain reaction. There were no statistically significant differences in the genetic frequencies of AURKA SNPs among patients with invasive cancer and those with precancerous lesions of uterine cervix and control women. There were no associations among AURKA SNPs and clinicopathologcal variables and recurrence and survival events. However, in a multivariate analysis, cervical cancer patients with adenocarcinoma (HR: 3.18, 95% CI: 1.23-8.23; p=0.017) and larger tumor (HR: 5.61, 95% CI: 2.10-14.95; p=0.001) had poorer recurrence-free survival. In conclusion, tumor size and pelvic lymph node status rather than AURKA SNPs were the most obvious independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.
Competing Interests: Competing Interests: The authors have declared that no competing interest exists.
(© The author(s).)

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