Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

The transcriptional regulator Zur regulates the expression of ZnuABC and T6SS4 in response to stresses in Yersinia pseudotuberculosis.

Tytuł:
The transcriptional regulator Zur regulates the expression of ZnuABC and T6SS4 in response to stresses in Yersinia pseudotuberculosis.
Autorzy:
Cai R; Beijing Capital Co., LTD, Beijing, 100044, China.
Gao F; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Pan J; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Hao X; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Yu Z; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Qu Y; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Li J; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Wang D; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Wang Y; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Shen X; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Liu X; General Research Institute for Nonferrous Metals, Beijing, 100088, China. Electronic address: .
Yang Y; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China. Electronic address: .
Źródło:
Microbiological research [Microbiol Res] 2021 Aug; Vol. 249, pp. 126787. Date of Electronic Publication: 2021 May 10.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Jena : G. Fischer, c1994-
MeSH Terms:
Gene Expression Regulation, Bacterial*
Oxidative Stress*
Bacterial Proteins/*genetics
Transcription Factors/*metabolism
Type VI Secretion Systems/*genetics
Yersinia pseudotuberculosis/*genetics
Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Bacterial Proteins/metabolism ; Operon ; Porins/genetics ; Porins/metabolism ; Promoter Regions, Genetic ; Type VI Secretion Systems/metabolism ; Yersinia pseudotuberculosis/physiology ; Zinc/metabolism
Contributed Indexing:
Keywords: Oxidative stress resistance; T6SS4; Transcriptional regulator; Zinc acquisition; ZnuABC; Zur
Substance Nomenclature:
0 (Bacterial Proteins)
0 (Porins)
0 (Transcription Factors)
0 (Type VI Secretion Systems)
EC 3.6.1.- (Adenosine Triphosphatases)
J41CSQ7QDS (Zinc)
Entry Date(s):
Date Created: 20210515 Date Completed: 20211022 Latest Revision: 20211022
Update Code:
20240105
DOI:
10.1016/j.micres.2021.126787
PMID:
33991717
Czasopismo naukowe
Zinc homeostasis is crucial for the development and stress resistance of bacteria in the environment. Serial zinc sensing transcriptional regulators, zinc transporters and zinc binding proteins were found to maintain the zinc homeostasis in bacteria. Zur is a zinc uptake regulator that is widely distributed in species, and ZnuABC, as well as the Type VI Secretion System (T6SS4) function in zinc acquisition. Here, we report that the regulator Zur inhibits the expression of the ZnuABC which inhibition could be eliminated at low zinc level, and upregulates the T6SS4 operon in Yersinia pseudotuberculosis to facilitate Zn 2+ uptake and oxidative stress resistance. Zur regulates the expression of ZnuABC and T6SS4 by directly binding to their promoter regions. Zur senses the Zn 2+ concentration and represses ZnuABC in a Zn 2+ -containing environment. Zur works as an auxiliary regular activator of T6SS4, facilitating oxidative stress resistance. This study revealed the dual function of regulator Zur on ZnuABC and T6SS4, and enriched the knowledge of Zn 2+ homeostasis maintenance in Y. pseudotuberculosis.
(Copyright © 2021 Elsevier GmbH. All rights reserved.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies