Computed tomography enterography for crohn's disease: correlation between the imaging findings and histopathologic scoring system.

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Tytuł:: Computed tomography enterography for crohn's disease: correlation between the imaging findings and histopathologic scoring system.
Autorzy:: Ma L; Department of Radiology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399, Wanyuan Road, Minhang District, Shanghai, 201102, China.
Shen X; Department of Radiology, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, No. 189, Chaoyang Road, Kunshan, 215300, Jiangsu Province, China.
Chen YJ; Department of Pathology, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, No. 189, Chaoyang Road, Kunshan, 215300, Jiangsu Province, China.
Zhang Q; Department of Blood Transfusion, Huashan Hospital, Fudan University, No. 12, Urumqi Rd, Jing'an District, Shanghai, 200041, China.
Li B; Department of Medical Imaging, Renji Hospital, Medical School of Jiaotong University, Shanghai, China, No. 160, Pujian Road, Pudong District, Shanghai, 200127, China. .
Zhang W; Department of Medical Imaging, Renji Hospital, Medical School of Jiaotong University, Shanghai, China, No. 160, Pujian Road, Pudong District, Shanghai, 200127, China. .
Źródło:: Abdominal radiology (New York) [Abdom Radiol (NY)] 2021 Sep; Vol. 46 (9), pp. 4121-4129. Date of Electronic Publication: 2021 May 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [New York] : Springer, [2016]-
MeSH Terms:: Crohn Disease*/diagnostic imaging
Female ; Humans ; Inflammation ; Male ; Mesentery/diagnostic imaging ; Retrospective Studies ; Tomography, X-Ray Computed
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Contributed Indexing:: Keywords: Computed tomography enterography; Crohn’s disease; Histopathologic score
Entry Date(s):: Date Created: 20210516 Date Completed: 20210831 Latest Revision: 20220707
Update Code:: 20240105
DOI:: 10.1007/s00261-021-03112-w
PMID:: 33993318
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Objectives: The aim of this study was to retrospectively determine if quantitative measurements of computed tomography enterography (CTE) imaging findings correlate with histopathologic scores from biopsy specimens in patients with Crohn's disease (CD).
Methods: CTE datasets of 34 CD patients (19 male and 15 female) who underwent endoscopy with biopsy within 25 days before or after CTE were retrospectively reviewed. CTE findings of segmental mural hyperenhancement, wall thickening, mural stratification and mesenteric findings were quantitatively measured in the corresponding segment. Histopathologic score of CD was based upon the Naini Cortina scoring system. Correlation between CTE findings and histopathologic scores was assessed using Spearman's rank correlation and logistic or linear regression analysis.
Results: Neutrophilic inflammation contributed the most to the segmental mural hyperenhancement and explained 38.4% of the variance (R 2 = 0.384, P = 0.006). Moreover, the increased lymphocytes and plasma cells predicted larger lymph node (P = 0.003) and increased attenuation in mesenteric fat (P = 0.022).
Conclusions: To a certain extent, macroscopic CTE findings may reflect the microscopic histopathologic state in the inflammatory stage of CD, underscoring that establishment of CTE scoring system may potentially provide an objective tool for assessment of disease progression.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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