Identification and whole-genome characterization of a novel Porcine Circovirus 3 subtype b strain from swine populations in Vietnam.

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Tytuł:: Identification and whole-genome characterization of a novel Porcine Circovirus 3 subtype b strain from swine populations in Vietnam.
Autorzy:: Nguyen NH; Department of Infectious Diseases and Veterinary Public Health Faculty of Animal Science and Veterinary Medicine, Nonglam University HCMC, Thu Duc district, Ho Chi Minh City, Vietnam. .; Han-Viet Veterinary Diagnosis Laboratory, Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Vietnam. .
Do Tien D; Department of Infectious Diseases and Veterinary Public Health Faculty of Animal Science and Veterinary Medicine, Nonglam University HCMC, Thu Duc district, Ho Chi Minh City, Vietnam.
Nguyen TQ; Han-Viet Veterinary Diagnosis Laboratory, Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Vietnam.
Nguyen TT; Han-Viet Veterinary Diagnosis Laboratory, Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Vietnam.
Nguyen MN; Research Center for Genetics and Reproductive Health, School of Medicine, Vietnam National University Ho Chi Minh City, Linh Trung ward, Thu Duc district, Ho Chi Minh City, Vietnam. .
Źródło:: Virus genes [Virus Genes] 2021 Aug; Vol. 57 (4), pp. 385-389. Date of Electronic Publication: 2021 May 16.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Boston Ma : Kluwer Academic
Original Publication: Boston, USA : M. Nijhoff, 1987-
MeSH Terms:: Whole Genome Sequencing*
Circovirus/*genetics
Genome, Viral/*genetics
Porcine Postweaning Multisystemic Wasting Syndrome/*genetics
Animals ; Circovirus/pathogenicity ; Porcine Postweaning Multisystemic Wasting Syndrome/virology ; Swine/virology ; Vietnam
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Contributed Indexing:: Keywords: Abortion; Circovirus; PCV3 genotype; Porcine circovirus type 3; Whole genome sequence
Entry Date(s):: Date Created: 20210516 Date Completed: 20210910 Latest Revision: 20210910
Update Code:: 20240105
DOI:: 10.1007/s11262-021-01844-x
PMID:: 33993380
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Porcine circovirus 3 (PCV3) is a novel circovirus detected in pigs suffering from porcine dermatitis and nephropathy syndrome (PDNS), reproductive failure, and multisystemic infection. In this study, we identified PCV3 infection in aborted fetuses and reported the full-length genome sequence of a PCV3 strain identified from southern Vietnam. The complete genome of this PCV3 strain is 2000 nucleotides in length. We found that it shares 98.5-99.25% sequence identity with other reference sequences and that it clusters with the PCV3b subtype. Several specific mutated sites were found to be unique to this Vietnamese PCV3b strain, including I14M in the Rep protein and K139R, I150F, and P169T in the Cap protein. The sequence data that have been made publically available as part of this study will help investigators to better understand the molecular characteristics, genetic diversity, and evolutionary history of PCV3. Careful and in-depth investigations into the epidemiology, pathogenicity, and the evolution of this novel virus is a matter of urgent economic and agricultural interest in Vietnam.

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