Expression and prognosis analyses of CASP1 in acute myeloid leukemia.

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Abstrakt

Tytuł:: Expression and prognosis analyses of CASP1 in acute myeloid leukemia.
Autorzy:: Liu J; The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong, People's Republic of China.
Zhao M; The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong, People's Republic of China.
Feng X; The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong, People's Republic of China.
Zeng Y; The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong, People's Republic of China.
Lin D; The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong, People's Republic of China.
Źródło:: Aging [Aging (Albany NY)] 2021 May 17; Vol. 13 (10), pp. 14088-14108. Date of Electronic Publication: 2021 May 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Albany, NY : Impact Journals, LLC
MeSH Terms:: Gene Expression Regulation, Leukemic*/drug effects
Caspase 1/*genetics
Leukemia, Myeloid, Acute/*genetics
Caspase 1/metabolism ; Caspase Inhibitors/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Gene Ontology ; Gene Regulatory Networks/drug effects ; Humans ; Leukemia, Myeloid, Acute/enzymology ; Leukemia, Myeloid, Acute/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Molecular Sequence Annotation ; Prognosis ; Protein Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Racial Groups ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects
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Contributed Indexing:: Keywords: AML; CASP1; apoptosis; expression; prognosis
Substance Nomenclature:: 0 (Caspase Inhibitors)
0 (MicroRNAs)
0 (RNA, Messenger)
0 (Transcription Factors)
EC 2.7.- (Protein Kinases)
EC 3.4.22.36 (Caspase 1)
Entry Date(s):: Date Created: 20210517 Date Completed: 20210720 Latest Revision: 20211204
Update Code:: 20240105
PubMed Central ID:: PMC8202835
DOI:: 10.18632/aging.203028
PMID:: 33999861
: Czasopismo naukowe

Caspase1 (CASP1) is a gene that encodes multiple proteins related to cell death. Nevertheless, the function of CASP1 in the pathogenesis of AML is still unclear. In the present study, a detailed analysis of cancer versus normal samples was performed to explore the relationship between CASP1 and leukemia. We used sequencing data from multiple cancer gene databases to analyze the gene expression and regulatory network of CASP1 in leukemia. We discovered that mRNA expression levels of CASP1 are increased in leukemia cell lines, especially in acute myelocytic leukemia (AML). Then, we verified the mRNA expression of CASP1 in AML clinical samples and observed significantly higher expression of CASP1 in relapsed AML patients. High CASP1 expression was associated with poor prognosis and CASP1 inhibition could impair the proliferation of AML cells. Related functional network identification suggests that CASP1 regulates apoptosis, immune and inflammatory response via pathways involving LYN, LCK, and the E2F family. These findings suggest that CASP1 probably contributes to the pathogenesis, and identify CASP1 as a factor for predicting the prognosis and as a therapeutic target of AML patients.

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