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Tytuł:
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Live poultry feeding and trading network and the transmission of avian influenza A(H5N6) virus in a large city in China, 2014-2015.
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Autorzy:
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Zhang R; Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
Lei Z; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China.
Liu C; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China.
Zhu Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China.
Chen J; Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
Yao D; Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
Ou X; Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
Ye W; Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
Huang Z; Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
Luo L; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China.
Sun B; Changsha Center for Disease Control and Prevention, Changsha, Hunan Province, People's Republic of China.
Chen T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China. Electronic address: .
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Źródło:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Jul; Vol. 108, pp. 72-80. Date of Electronic Publication: 2021 May 14.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Hamilton, ON : Elsevier
Original Publication: Hamilton, ON : Decker, c1996-
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MeSH Terms:
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Influenza A virus*
Influenza in Birds*/epidemiology
Influenza, Human*/epidemiology
Animals ; China/epidemiology ; Humans ; Phylogeny ; Poultry
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Contributed Indexing:
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Keywords: Avian influenza virus; H5N6; Live poultry market; Network; Transmission
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Entry Date(s):
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Date Created: 20210517 Date Completed: 20210819 Latest Revision: 20210819
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Update Code:
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20240104
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DOI:
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10.1016/j.ijid.2021.05.022
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PMID:
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34000420
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Objectives: To understand the transmission mechanisms of the avian influenza A(H5N6) virus.
Methods: This study explored the live poultry feeding and trading network (LPFTN) around Changsha city, China. Field epidemiological investigations were performed in Changsha to investigate the LPFTN with the environmental samples systematically collected during 2014-2015 to monitor and analyze the spread of the A(H5N6) virus. Two surveillance systems were also applied to find possible human cases of A(H5N6) infection.
Result: The information of all the 665 live poultry farming sites, five wholesale markets, and 223 retail markets in Changsha was collected to investigate the LPFTN. Moreover, about 840 environmental samples were systematically collected from the LPFTN during 2014-2015 to monitor the spread of the A(H5N6) virus, with 8.45% (71/840) positive for the N6 subtype. Furthermore, the full genome sequences of 10 A(H5N6) viruses detected from the environmental samples were obtained, which were then characterized and phylogenetically analyzed with the corresponding gene segments of the A(H5N6) virus obtained from GenBank, to determine the source of human infection.
Conclusion: It was demonstrated that the LPFTN provided a platform for the H5N6 transmission, and formed an infectious pool for the spread of the virus to humans.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
