Weight trajectories and abdominal adiposity in COVID-19 survivors with overweight/obesity.

Szczegóły
Abstrakt

Tytuł:: Weight trajectories and abdominal adiposity in COVID-19 survivors with overweight/obesity.
Autorzy:: Di Filippo L; Vita-Salute San Raffaele University, Milan, Italy.; Institute of Endocrine and Metabolic Sciences, IRCCS San Raffaele Hospital, Milan, Italy.
De Lorenzo R; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Cinel E; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Falbo E; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Ferrante M; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Cilla M; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Martinenghi S; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Vitali G; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Bosi E; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Giustina A; Vita-Salute San Raffaele University, Milan, Italy.; Institute of Endocrine and Metabolic Sciences, IRCCS San Raffaele Hospital, Milan, Italy.
Rovere-Querini P; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy.
Conte C; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Milan, Italy. .; Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open, University, Rome, Italy. .
Źródło:: International journal of obesity (2005) [Int J Obes (Lond)] 2021 Sep; Vol. 45 (9), pp. 1986-1994. Date of Electronic Publication: 2021 May 17.
Typ publikacji:: Journal Article; Observational Study
Język:: English
Imprint Name(s):: Original Publication: London : Nature Pub. Group, c2005-
MeSH Terms:: Body-Weight Trajectory*
Survivors*
COVID-19/*physiopathology
Obesity, Abdominal/*physiopathology
Overweight/*physiopathology
Adiposity ; Aged ; Anthropometry ; Female ; Hospitalization ; Humans ; Italy ; Male ; Middle Aged ; Obesity, Abdominal/virology ; Overweight/virology ; Prospective Studies ; Waist Circumference
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Molecular Sequence:: ClinicalTrials.gov NCT04318366
Entry Date(s):: Date Created: 20210518 Date Completed: 20210909 Latest Revision: 20230203
Update Code:: 20240104
PubMed Central ID:: PMC8127478
DOI:: 10.1038/s41366-021-00861-y
PMID:: 34002039
: Czasopismo naukowe

Background: COVID-19 is associated with unintentional weight loss. Little is known on whether and how patients regain the lost weight. We assessed changes in weight and abdominal adiposity over a three-month follow-up after discharge in COVID-19 survivors.
Methods: In this sub-study of a large prospective observational investigation, we collected data from individuals who had been hospitalized for COVID-19 and re-evaluated at one (V1) and three (V2) months after discharge. Patient characteristics upon admission and anthropometrics, waist circumference and hunger levels assessed during follow-up were analyzed across BMI categories.
Results: One-hundred-eighty-five COVID-19 survivors (71% male, median age 62.1 [54.3; 72.1] years, 80% with overweight/obesity) were included. Median BMI did not change from admission to V1 in normal weight subjects (-0.5 [-1.2; 0.6] kg/m 2 , p = 0.08), but significantly decreased in subjects with overweight (-0.8 [-1.8; 0.3] kg/m 2 , p < 0.001) or obesity (-1.38 [-3.4; -0.3] kg/m 2 , p < 0.001; p < 0.05 vs. normal weight or obesity). Median BMI did not change from V1 to V2 in normal weight individuals (+0.26 [-0.34; 1.15] kg/m 2 , p = 0.12), but significantly increased in subjects with overweight (+0.4 [0.0; 1.0] kg/m 2 , p < 0.001) or obesity (+0.89 [0.0; 1.6] kg/m 2 , p < 0.001; p = 0.01 vs. normal weight). Waist circumference significantly increased from V1 to V2 in the whole group (p < 0.001), driven by the groups with overweight or obesity. At multivariable regression analyses, male sex, hunger at V1 and initial weight loss predicted weight gain at V2.
Conclusions: Patients with overweight or obesity hospitalized for COVID-19 exhibit rapid, wide weight fluctuations that may worsen body composition (abdominal adiposity). CLINICALTRIALS.
Gov Registration: NCT04318366.
(© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)

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