A meta-analysis of randomized controlled trials of a traditional Chinese medicine prescription, modified RunChang-Tang, in treating functional constipation.

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Abstrakt

Tytuł:: A meta-analysis of randomized controlled trials of a traditional Chinese medicine prescription, modified RunChang-Tang, in treating functional constipation.
Autorzy:: Zhao X; Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu.
Fang Y; Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu.
Ye J; Department of Respiratory Medicine, Mianyang Hospital of T.C.M, Mianyang.
Qin F; Andrology Laboratory, Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Lu W; Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu.
Gong H; Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu.
Źródło:: Medicine [Medicine (Baltimore)] 2021 May 21; Vol. 100 (20), pp. e25760.
Typ publikacji:: Comparative Study; Journal Article; Meta-Analysis
Język:: English
Imprint Name(s):: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
MeSH Terms:: Constipation/*drug therapy
Drugs, Chinese Herbal/*administration & dosage
Laxatives/*administration & dosage
Prescription Drugs/*administration & dosage
China ; Constipation/diagnosis ; Flax/chemistry ; Humans ; Laxatives/adverse effects ; Prescription Drugs/adverse effects ; Randomized Controlled Trials as Topic ; Rheum/chemistry ; Treatment Outcome
References:: Gallegos-Orozco JF, Foxx-Orenstein AE, Sterler SM, et al. Chronic constipation in the elderly. Am J Gastroenterol 2012;107:18–25.
Schmidt FM, Santos VL. Prevalence of constipation in the general adult population: an integrative review. J Wound Ostomy Continence Nurs 2014;41:70–6.
Zhao YF, Ma XQ, Wang R, et al. Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC). Aliment Pharmacol Ther 2011;34:1020–9.
Mugie SM, Benninga MA, Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol 2011;25:03–18.
Belsey J, Greenfield S, Candy D, et al. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 2010;31:938–49.
Wald A, Scarpignato C, Kamm MA, et al. The burden of constipation on quality of life: results of a multinational survey. Aliment Pharmacol Ther 2007;26:227–36.
Sethi S, Mikami S, Leclair J, et al. Inpatient burden of constipation in the United States: an analysis of national trends in the United States from 1997 to 2010. Am J Gastroenterol 2014;109:250–6.
Sun SX, Dibonaventura M, Purayidathil FW, et al. Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the national health and wellness survey. Dig Dis Sci 2011;56:2688–95.
Cai LW, Wang YJ, Qian WZ. Effect of Huoxue Yiqi Runchang Decoction in the treatment of chronic intractable constipation in colonic dynamics. Chin J Biochem Pharm 2016;36:137–9.
Chen WF, Yang BK. Yiyuanrunchangtang treatment of senile constipation random parallel control study. J Pract Tradit Chin Intern Med 2014;28:20–1.
Deng YG, Fu P, Deng LL, et al. Treatment of 50 cases of habitual constipation in elderly patients with deficiency of yin-blood by Yangxue Runchang Decoction. Jiangxi J Tradit Chin Med 2015;46:52–3.
Fang X, Qian HH. Treatment of 31 cases of chronic transmission constipation with Yangyin Runchang Decoction. Nei Mongol J Tradit Chin Med 2017;36:50–1.
Han YB. A randomized parallel controlled study of Jianpi Runchang Tongji Decoction in the treatment of functional constipation of spleen deficiency and intestinal dryness type. J Pract Tradit Chin Intern Med 2015;29:42–3.
Hou YJ, Huang L, Fu P. The clinical observation on the treatment of functional constipation by combination of chinese and western medicine. J Pract Tradit Chin Med 2014;30:42–3.
Jiang C. Observation and analysis of the application effect of Jianpi Runchang Decoction in senile constipation. Contemp Med 2016;22:51–152.
Li SB. Clinical research of Yiqi Runchang Tang on treating the middle-aged and the elderly patients with functional constipation [M.S. Thesis]. Guangzhou, China: Guangzhou University of Chinese Medicine; 2009.
Li JH, Jiang YP. Self-made Yiqi Yangxue Runchang Decoction in the treatment of 30 cases of habitual constipation in the elderly. Jiangxi J Tradit Chin Med 2013;44:27–8.
Lu K, Yuan FY, Zhao YC, et al. Treatment of 25 cases of senile habitual constipation with Yiqi Yangxue Runchang Decoction. Mod Tradit Chin Med 2011;31:18–9.
Ren AM. The clinical study on the treatment of functional constipation of jin shortage and blood deficiency type by Modifided Runchang Wan Decoction [M.S. Thesis]. Naniing, China: Nanjing University of Chinese Medicine; 2014.
Shi C, He Y, Zhou JH. Clinical observation on 30 cases of functional constipation treated by supplementing qi and nourishing yin methods. Jilin J Chin Med 2008;28:26–7.
Song QZ, Zhang L, Tang SY. Treatment of 36 cases of constipation type irritable bowel syndrome with Jianpi Runchang Decoction. Forum Tradit Chin Med 2007;22:26–7.
Sun JH. Clinical observation of Wenpi runchang decoction in treating slow transit constipation. Shanghai J Tradit Chin Med 2007;41:44–5.
Tang SJ, Chen MW, Gu CY. Summary of 51 cases of senile functional constipation treated by Ziyin Jianpi Runchang Prescription. Hunan J Tradit Chin Med 2009;25:29–30.
Wan F, Fu P, Li LF. Treatment of 45 cases of habitual constipation in the elderly with qi and blood deficiency due to Yiqi Yangxue Runchang Decoction. Pract Clin J Integr Tradit Chin West Med 2016;16:66–7.
Wang KP. Shugan Liqi Runchang Decoction in the treatment of 36 cases of constipation type irritable bowel syndrome, compared with 30 cases of cisapride treatment. Zhejiang J Tradit Chin Med 2004;39:21.
Wei LP. Clinical research of Yiqiyangyinrunchang Decoction in the treatment of senile functional constipation of qi and yin deficiency type [M.S. Thesis]. Zhengzhou, China: Henan University of Chinese Medicine; 2016.
Wu GL. Clinical effect observation of Yiqi Runchang Daozhi Decoction treating qi and yin deficiency type constipation (slow transit) [M.S. Thesis]. Jinan, China: Shandong University of Traditional Chinese Medicine; 2013.
Xin H, Wang XP, Zhang JQ, et al. Runchang Tongbian Decoction for the treatment of senile functional constipation. Shanghai J Tradi Chin Med 2014;48:43–4.
Xu RH. Treatment of 80 cases of senile constipation with Yiqi Runchang Decoction. Chin Med Mod Dist Educ CHN 2010;8:33.
Yang XJ. Clinical observation on 47 cases of slow transit constipation treated by Sanshen Runchang Decoction. Guid J Tradit Chin Med Pharm 2010;16:37–8.
Yang JY, Liu XY, Li KG, et al. Clinical observation of Runchang Wan Decoction in treating functional constipation of jin shortage and blood deficiency type. World Latest Med Inform 2017;17:125–6.
Zhang YX. Clinical efficacy of Baizi Ziyin Runchang Decoction in the treatment of chronic functional constipation. Guangming J Chin Med 2015;30:792–3.
Zhang Y. The Therapeutic effect observation of Huoxue Yiqi Runchang Decoction on chronic intractable constipation. Chin J Ethnomed Ethnopharm 2018;27:100–1.
Zhao HX. The therapeutic effect observation of self-made Yiqi Runchang Decoction on 42 cases of senile constipation. Chin Community Doct 2011;13:177–8.
Su X, Yao Z, Li S, et al. Synergism of Chinese herbal medicine: illustrated by Danshen compound. Evid Based Complement Alternat Med 2016;7279361.
Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther 2007;25:599–608.
van Tilburg MA, Palsson OS, Levy RL, et al. Complementary and alternative medicine use and cost in functional bowel disorders: a six month prospective study in a large HMO. BMC Complement Altern Med 2008;8:46.
Tan N, Gwee KA, Tack J, et al. Herbal medicine in the treatment of functional gastrointestinal disorders: a systematic review with meta-analysis. J Gastroenterol Hepatol 2020;35:544–56.
Gong H, Qin F, He H. Herbal formula Modified Buzhong-Yiqi-Tang for functional constipation in adults: a Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med 2018;9602525.
Jiang F, Zhou JYS Wu##J, et al. Yangyin Runchang Decoction improves intestinal motility in mice with atropine/diphenoxylate-induced slow-transit constipation. Evid Based Complement Alternat Med 2017;4249016.
Han K, Bose S, Kim YM, et al. Rehmannia glutinosa reduced waist circumferences of Korean obese women possibly through modulation of gut microbiota. Food Funct 2015;6:2684–92.
Ma BL, Ma YM. Pharmacokinetic herb-drug interactions with traditional Chinese medicine: progress, causes of conflicting results and suggestions for future research. Drug Metab Rev 2016;48:01–26.
Grant Information:: 2015SZ0134 Department of Science and Technology of Sichuan Province
Substance Nomenclature:: 0 (Drugs, Chinese Herbal)
0 (Laxatives)
0 (Prescription Drugs)
Entry Date(s):: Date Created: 20210520 Date Completed: 20210526 Latest Revision: 20230103
Update Code:: 20240104
PubMed Central ID:: PMC8137032
DOI:: 10.1097/MD.0000000000025760
PMID:: 34011036
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Background: Modified Runchang-Tang (MRCT), a Chinese herbal medicine, is widely used to treat functional constipation (FC), which is a common digestive system disease. However, its efficacy has not been evaluated systematically and objectively. Thus, a meta-analysis was conducted to assess the efficacy and safety of MRCT for treating functional constipation.
Methods: We searched for relevant publications from Embase, Medline, The Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journals Database, and Wanfang Data for relevant literature. The timeframe of retrieval was set from the founding date of each database to July 15, 2020.
Result: A total of 26 randomized controlled trials with 2103 individuals were included in this meta-analysis. All trials were conducted in mainland China and were written in Chinese. The results showed that MRCT monotherapy provided better symptom relief in FC patients compared to prokinetic agent monotherapy (odds ratio, [OR] = 4.06), osmotic laxatives (OR = 4.39) and stimulant laxatives (OR = 2.99). Additionally, there were no obvious adverse effects in MRCT group compared with control group.
Conclusion: MRCT treatment is an efficient and safe treatment for FC. However, considering the limitations of this study, further well-designed randomized controlled trials are required to validate this conclusion.
Competing Interests: The authors have no conflicts of interest to disclose.
(Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)

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