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Tytuł:
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The Expanding Role of Chemistry in Optimizing Proteins for Human Health Applications.
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Autorzy:
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Roman BI; Research Group SynBioC, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Universiteit Gent, Coupure Links 653, 9000 Gent, Belgium.; Cancer Research Institute Ghent (CRIG), Corneel Heymanslaan 10, 9000 Gent, Belgium.
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Źródło:
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Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7179-7188. Date of Electronic Publication: 2021 May 20.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Washington Dc : American Chemical Society
Original Publication: [Easton, Pa.] : American Chemical Society, [c1963-
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MeSH Terms:
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Chemistry, Pharmaceutical*
Proteins/*chemistry
Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/metabolism ; Humans ; Immunoconjugates/chemistry ; Immunoconjugates/metabolism ; Immunoconjugates/therapeutic use ; Leukemia/drug therapy ; Protein Processing, Post-Translational ; Proteins/immunology ; Proteins/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism
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Substance Nomenclature:
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0 (Antibodies, Monoclonal)
0 (Immunoconjugates)
0 (Proteins)
0 (Small Molecule Libraries)
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Entry Date(s):
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Date Created: 20210520 Date Completed: 20210617 Latest Revision: 20210617
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Update Code:
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20240104
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DOI:
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10.1021/acs.jmedchem.1c00294
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PMID:
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34014084
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Over the past decades, therapeutics based on biological macromolecules and cells have successfully entered the clinical arena and progressively occupied an increasing share of what once was almost exclusively small molecule territory. This perspective explores the opportunities for chemists at the interface between biologics and small molecule-based products. It provides concrete examples by zooming in on the area of post-translational protein modification. The conclusion is that, rather than diminishing the relevance of chemistry in the pharmaceutical enterprise, the advent of the biologics has provided an additional playing field for synthetic and medicinal chemists, where they can contribute to the efficacy and scope of applicability of biological entities in a collaborative effort to transformatively address unmet medical needs.