Efficacy of ginger as antiemetic in children with acute gastroenteritis: a randomised controlled trial.

Tytuł:: Efficacy of ginger as antiemetic in children with acute gastroenteritis: a randomised controlled trial.
Autorzy:: Nocerino R; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy.
Cecere G; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
Micillo M; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
De Marco G; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
Ferri P; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
Russo M; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
Bedogni G; CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy.; Clinical Epidemiology Unit, Liver Research Center, Basovizza, Trieste, Italy.
Berni Canani R; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy.; European Laboratory for the Investigation of Food-induced Diseases, University of Naples Federico II, Naples, Italy.; Task Force on Microbiome Studies, University of Naples Federico II, Naples, Italy.
Źródło:: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2021 Jul; Vol. 54 (1), pp. 24-31. Date of Electronic Publication: 2021 May 21.
Typ publikacji:: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Oxford : Wiley-Blackwell
Original Publication: [Oxford, OX] : Blackwell Scientific Publications, [c1987-
MeSH Terms:: Antiemetics*/therapeutic use
Gastroenteritis*/complications
Gastroenteritis*/drug therapy
Zingiber officinale*
Child ; Double-Blind Method ; Humans ; Nausea ; Treatment Outcome ; Vomiting/drug therapy ; Vomiting/prevention & control
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Molecular Sequence:: ClinicalTrials.gov NCT02701491
Substance Nomenclature:: 0 (Antiemetics)
Entry Date(s):: Date Created: 20210521 Date Completed: 20210625 Latest Revision: 20240109
Update Code:: 20240109
PubMed Central ID:: PMC8252074
DOI:: 10.1111/apt.16404
PMID:: 34018223
: Czasopismo naukowe

Pełny tekst

Background: Ginger is a spice with a long history of use as a traditional remedy for nausea and vomiting. No data on the efficacy of ginger are presently available for children with vomiting associated with acute gastroenteritis (AGE).
Aim: To test whether ginger can reduce vomiting in children with AGE.
Methods: Double-blind, randomised placebo-controlled trial in outpatients aged 1 to 10 years with AGE-associated vomiting randomised to ginger or placebo. The primary outcome was the occurrence of ≥1 episode of vomiting after the first dose of treatment. Severity of vomiting and safety were also assessed.
Results: Seventy-five children were randomised to the ginger arm and 75 to the placebo arm. Five children in the ginger arm and 4 in the placebo arm refused to participate in the study shortly after randomisation, leaving 70 children in the ginger arm and 71 in the placebo arm (N = 141). At intention-to-treat analysis (N = 150), assuming that all children lost to follow-up had reached the primary outcome, the incidence of the main outcome was 67% (95% CI 56 to 77) in the ginger group and 87% (95% CI 79 to 94) in the placebo group, corresponding to the absolute risk reduction for the ginger versus the placebo group of -20% (95% CI -33% to -7%, P = 0.003), with a number needed to treat of 5 (95% CI 3 to 15).
Conclusion: Oral administration of ginger is effective and safe at improving vomiting in children with AGE.
Trial Registration: The trial was registered on https://clinicaltrials.gov/ with the identifier NCT02701491.
(© 2021 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)

Comment in: Aliment Pharmacol Ther. 2021 Sep;54(6):858-859. (PMID: 34425005)
Comment in: Aliment Pharmacol Ther. 2021 Sep;54(6):860-861. (PMID: 34425012)

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