Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

The Bacillus virulome in endophthalmitis.

Tytuł :
The Bacillus virulome in endophthalmitis.
Autorzy :
Coburn PS; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Miller FC; Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Enty MA; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Land C; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
LaGrow AL; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Mursalin MH; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Callegan MC; Dean McGee Eye Institute, Oklahoma City, Oklahoma, USA.; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Pokaż więcej
Źródło :
Microbiology (Reading, England) [Microbiology (Reading)] 2021 May; Vol. 167 (5).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Język :
English
Imprint Name(s) :
Publication: 2015- : London : Microbiology Society
Original Publication: Reading, U.K. : Society for General Microbiology, c1994-
References :
Clin Microbiol Infect. 2013 Mar;19(3):227-34. (PMID: 23438028)
Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3233-8. (PMID: 16123424)
Mol Microbiol. 2007 Oct;66(2):495-510. (PMID: 17897374)
Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3727-3739. (PMID: 31479113)
Infect Immun. 2003 Jun;71(6):3116-24. (PMID: 12761089)
J Bacteriol. 2000 Jun;182(11):3055-62. (PMID: 10809682)
Infect Immun. 1995 Feb;63(2):632-9. (PMID: 7822032)
Exp Eye Res. 2017 Jun;159:69-76. (PMID: 28336259)
J Exp Med. 2004 Dec 20;200(12):1647-55. (PMID: 15611291)
Mol Microbiol. 2001 May;40(3):731-43. (PMID: 11359578)
Nature. 2003 May 1;423(6935):87-91. (PMID: 12721630)
J Bacteriol. 1999 Mar;181(6):1939-43. (PMID: 10074093)
Microorganisms. 2020 Apr 22;8(4):. (PMID: 32331252)
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1003-7. (PMID: 18084079)
Infect Immun. 2008 Apr;76(4):1358-67. (PMID: 18268029)
Microbiol Mol Biol Rev. 2013 Jun;77(2):173-207. (PMID: 23699254)
Infect Immun. 2004 Jan;72(1):219-28. (PMID: 14688099)
J Clin Microbiol. 2002 Aug;40(8):3053-6. (PMID: 12149378)
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4918-23. (PMID: 9560203)
J Bacteriol. 2012 Jul;194(13):3377-85. (PMID: 22544275)
Infect Immun. 1999 Jul;67(7):3357-66. (PMID: 10377113)
J Bacteriol. 1996 May;178(10):2749-56. (PMID: 8631661)
Mol Microbiol. 1991 May;5(5):1081-9. (PMID: 1659648)
J Bacteriol. 1993 Nov;175(21):6760-6. (PMID: 7693651)
Curr Eye Res. 2006 Sep;31(9):693-702. (PMID: 16966141)
EMBO J. 2002 Sep 2;21(17):4550-9. (PMID: 12198157)
DNA Cell Biol. 2002 May-Jun;21(5-6):367-73. (PMID: 12167238)
Infect Immun. 1999 Jul;67(7):3348-56. (PMID: 10377112)
Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):17. (PMID: 33180117)
Front Immunol. 2020 Feb 12;11:215. (PMID: 32117322)
Biochim Biophys Acta. 2001 Sep 28;1537(2):132-46. (PMID: 11566257)
Appl Environ Microbiol. 2009 Jun;75(12):4111-9. (PMID: 19395575)
Infect Immun. 2002 Oct;70(10):5381-9. (PMID: 12228262)
Genes Dev. 1993 Jan;7(1):139-48. (PMID: 8422983)
PLoS One. 2014 Jun 24;9(6):e100543. (PMID: 24959742)
Curr Eye Res. 2006 Nov;31(11):955-65. (PMID: 17114121)
PLoS Pathog. 2016 Nov 29;12(11):e1006049. (PMID: 27898733)
Mol Microbiol. 2012 Jul;85(1):67-88. (PMID: 22571587)
Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4461-7. (PMID: 17003440)
Antonie Van Leeuwenhoek. 2014 Dec;106(6):1157-65. (PMID: 25227778)
Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4552-60. (PMID: 19420340)
PLoS Pathog. 2012;8(4):e1002629. (PMID: 22511867)
Front Microbiol. 2015 Oct 07;6:1004. (PMID: 26500610)
PLoS One. 2008 Jul 30;3(7):e2793. (PMID: 18665214)
J Bacteriol. 2007 Jul;189(14):5302-13. (PMID: 17496091)
FEMS Microbiol Lett. 2006 Apr;257(2):293-8. (PMID: 16553866)
Environ Microbiol. 2001 Aug;3(8):493-501. (PMID: 11578310)
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6711-5. (PMID: 2901103)
J Bacteriol. 2010 May;192(10):2638-42. (PMID: 20233921)
BMC Ophthalmol. 2018 Apr 16;18(1):96. (PMID: 29661181)
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1966-71. (PMID: 12569171)
Prog Retin Eye Res. 2007 Mar;26(2):189-203. (PMID: 17236804)
PLoS One. 2014 Jan 31;9(1):e87532. (PMID: 24498128)
Infect Immun. 2000 Sep;68(9):5269-76. (PMID: 10948154)
Microbes Infect. 2000 Jan;2(1):91-8. (PMID: 10717546)
Infect Immun. 2005 Oct;73(10):6479-87. (PMID: 16177320)
Grant Information :
P30 EY021725 United States EY NEI NIH HHS; R01 EY024140 United States EY NEI NIH HHS; R01 EY028810 United States EY NEI NIH HHS; R21 EY028066 United States EY NEI NIH HHS
Contributed Indexing :
Keywords: Bacillus cereus*; endophthalmitis*; ocular environment*; ocular infections*; virulence determinants*; vitreous*
Entry Date(s) :
Date Created: 20210525 Latest Revision: 20210910
Update Code :
20210914
PubMed Central ID :
PMC8345767
DOI :
10.1099/mic.0.001057
PMID :
34032564
Czasopismo naukowe
Bacillus cereus is recognized as a causative agent of gastrointestinal syndromes, but can also cause a devastating form of intraocular infection known as endophthalmitis. We have previously reported that the PlcR/PapR master virulence factor regulator system regulates intraocular virulence, and that the S-layer protein (SlpA) contributes to the severity of B. cereus endophthalmitis. To better understand the role of other B. cereus virulence genes in endophthalmitis, expression of a subset of factors was measured at the midpoint of disease progression in a murine model of endophthalmitis by RNA-Seq. Several cytolytic toxins were expressed at significantly higher levels in vivo than in BHI. The virulence regulators codY , gntR , and nprR were also expressed in vivo . However, at this timepoint, plcR / papR was not detectable, although we previously reported that a B. cereus mutant deficient in PlcR was attenuated in the eye. The motility-related genes fla , fliF , and motB , and the chemotaxis-related gene cheA were detected during infection. We have shown previously that motility and chemotaxis phenotypes are important in B. cereus endophthalmitis. The sodA2 variant of manganese superoxide dismutase was the most highly expressed gene in vivo . Expression of the surface layer protein gene, slpA , an activator of Toll-like receptors (TLR)-2 and -4, was also detected during infection, albeit at low levels. Genes expressed in a mouse model of Bacillus endophthalmitis might play crucial roles in the unique virulence of B. cereus endophthalmitis, and serve as candidates for novel therapies designed to attenuate the severity of this often blinding infection.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies