Immediate retrograde amnesia induced by midazolam: A prospective, non-randomised cohort study.

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Tytuł:: Immediate retrograde amnesia induced by midazolam: A prospective, non-randomised cohort study.
Autorzy:: Sohn HM; Department of Anesthesiology and Pain Medicine, Ajou University Hospital, Gyeonggi-do, Republic of Korea.
Na HS; Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Lim D; Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Koung Yi I; Department of Anesthesiology and Pain Medicine, Ajou University Hospital, Gyeonggi-do, Republic of Korea.
Nam SW; Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Do SH; Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.; Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Hwang JW; Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.; Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Źródło:: International journal of clinical practice [Int J Clin Pract] 2021 Nov; Vol. 75 (11), pp. e14402. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2022- : Mumbai : Hindawi
Original Publication: Esher [England] ; Bronxville, N.Y. : Medicom International, c1997-
MeSH Terms:: Amnesia, Retrograde*/chemically induced
Midazolam*/adverse effects
Cohort Studies ; Female ; Humans ; Hypnotics and Sedatives/adverse effects ; Pregnancy ; Prospective Studies
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Contributed Indexing:: Keywords: amnesia; memory; midazolam; retrograde
Substance Nomenclature:: 0 (Hypnotics and Sedatives)
R60L0SM5BC (Midazolam)
Entry Date(s):: Date Created: 20210526 Date Completed: 20211022 Latest Revision: 20211022
Update Code:: 20240105
DOI:: 10.1111/ijcp.14402
PMID:: 34037290
: Czasopismo naukowe

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Background: Midazolam, a short-acting benzodiazepine, has sedative, anxiolytic, amnestic and anticonvulsant effects. Given its advantages of rapid onset, short duration and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the possibility of retrograde amnesia has also been raised. This prospective cohort, non-randomised study evaluated the presence and extent of retrograde amnesia induced by midazolam during caesarean delivery.
Methods: One hundred parturients scheduled for elective caesarean delivery under spinal anaesthesia were enrolled. As soon as giving birth, six picture cards were shown to the patients in 1-min intervals, and then midazolam (0.1 mg/kg) was given or not according to the patients' preference. This overall retrograde recall rate of six cards was the primary outcome of our study, which was asked by a blinded investigator.
Results: The overall retrograde card recall rate was lower in the midazolam group compared with the control group (77.0 ± 13.4 vs. 87.7 ± 3.9%, P < .001), especially at 1 minute before midazolam administration (58% vs. 88%, P < .001). Decreased memory trend was observed as time progressed towards midazolam administration in the midazolam group (P = .035). More patients answered 'yes' to the factitious event in the midazolam group than in the control group (26% vs. 4%, P = .004).
Conclusion: Intravenous midazolam could cause a brief-period retrograde amnesia in visual and event memory. Moreover, there were more spurious reports of intraoperative factitious events in the midazolam group, implying that episodic memories were also affected by midazolam.
(© 2021 John Wiley & Sons Ltd.)

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