Nerve Guidance Conduits with Hierarchical Anisotropic Architecture for Peripheral Nerve Regeneration.

Szczegóły
Abstrakt

Tytuł:: Nerve Guidance Conduits with Hierarchical Anisotropic Architecture for Peripheral Nerve Regeneration.
Autorzy:: Lu Q; National Engineering Laboratory for Modern Silk and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.; School of Biology and Basic Medical Sciences, Soochow University, Suzhou, 215123, P. R. China.
Zhang F; National Engineering Laboratory for Modern Silk and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.; School of Biology and Basic Medical Sciences, Soochow University, Suzhou, 215123, P. R. China.
Cheng W; Department of Orthopedics, The First Affiliated Hospital of Xiamen University, Xiamen, 361000, P. R. China.
Gao X; National Engineering Laboratory for Modern Silk and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
Ding Z; National Engineering Laboratory for Modern Silk and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
Zhang X; National Engineering Laboratory for Modern Silk and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
Lu Q; National Engineering Laboratory for Modern Silk and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
Kaplan DL; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Źródło:: Advanced healthcare materials [Adv Healthc Mater] 2021 Jul; Vol. 10 (14), pp. e2100427. Date of Electronic Publication: 2021 May 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Weinheim : Wiley-VCH, 2012-
MeSH Terms:: Guided Tissue Regeneration*
Nanofibers*
Animals ; Nerve Regeneration ; PC12 Cells ; Rats ; Schwann Cells ; Sciatic Nerve ; Silk ; Tissue Scaffolds
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Grant Information:: P41 EB027062 United States EB NIBIB NIH HHS; R01 NS094218 United States NS NINDS NIH HHS
Contributed Indexing:: Keywords: hierarchical architecture; module assembly; nerve conduits; peripheral nerve regeneration; silk nanofibers
Substance Nomenclature:: 0 (Silk)
Entry Date(s):: Date Created: 20210526 Date Completed: 20210805 Latest Revision: 20231107
Update Code:: 20240105
PubMed Central ID:: PMC8295195
DOI:: 10.1002/adhm.202100427
PMID:: 34038626
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Nerve guidance conduits with multifunctional features could offer microenvironments for improved nerve regeneration and functional recovery. However, the challenge remains to optimize multiple cues in nerve conduit systems due to the interplay of these factors during fabrication. Here, a modular assembly for the fabrication of nerve conduits is utilized to address the goal of incorporating multifunctional guidance cues for nerve regeneration. Silk-based hollow conduits with suitable size and mechanical properties, along with silk nanofiber fillers with tunable hierarchical anisotropic architectures and microporous structures, are developed and assembled into conduits. These conduits supported improves nerve regeneration in terms of cell proliferation (Schwann and PC12 cells) and growth factor secretion (BDNF, brain-derived neurotrophic factor) in vitro, and the in vivo repair and functional recovery of rat sciatic nerve defects. Nerve regeneration using these new conduit designs is comparable to autografts, providing a path towards future clinical impact.
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