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Tytuł:
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CD4 T cell depletion does not affect the level of viremia in chronically SHIV SF162P3N -infected Chinese cynomolgus monkeys.
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Autorzy:
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Liu H; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Liu JB; Guangdong Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, 510632, China.
Meng FZ; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Xu XQ; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Wang Y; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Xian QY; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Zhou RH; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Xiao QH; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Huang ZX; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Zhou L; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Li JL; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Li XD; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China.
Wang X; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Ho WZ; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA. Electronic address: .
Zhuang K; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, PR China. Electronic address: .
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Źródło:
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Virology [Virology] 2021 Aug; Vol. 560, pp. 76-85. Date of Electronic Publication: 2021 May 07.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: New York, Academic Press.
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MeSH Terms:
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Lymphocyte Depletion*
CD4-Positive T-Lymphocytes/*immunology
Simian Immunodeficiency Virus/*immunology
Viremia/*blood
Virus Replication/*immunology
Animals ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/cytology ; China ; Cytokines/biosynthesis ; Cytokines/blood ; Disease Progression ; Female ; Lymphocyte Activation/immunology ; Macaca fascicularis ; Macrophages/immunology ; Macrophages/virology ; Proof of Concept Study ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Viral Load
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Contributed Indexing:
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Keywords: CD4(+) T cell; Cynomolgus; Depletion; SHIV; Viremia
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Substance Nomenclature:
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0 (Cytokines)
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Entry Date(s):
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Date Created: 20210529 Date Completed: 20220106 Latest Revision: 20220106
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Update Code:
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20240105
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DOI:
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10.1016/j.virol.2021.04.012
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PMID:
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34051477
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Chronically SHIV SF162P3N -infected cynomolgus monkeys were used to determine the effects of the antibody-mediated acute CD4 + T cell depletion on viral load as well as on the immunological factors associated with disease progression. Compared with the control animals, CD4 + T cell-depleted animals with SHIV infection showed (i) little alteration in plasma viral load over the period of 22 weeks after the depletion; (ii) increased CD4 + T cell proliferation and turnover of macrophages at the early phase of the depletion, but subsequent decline to the basal levels; and (iii) little impact on the expression of the inflammatory cytokines and CC chemokines associated with disease progression. These findings indicate that the antibody-mediated acute CD4 + T cell depletion had minimal impact on plasma viral load and disease progression in chronically SHIV SF162P3N -infected cynomolgus monkeys. Future investigations are necessary to identify the key factor(s) related to the immune activation and macrophage infection during the CD4 deletion in chronic viral infection.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
