A preliminary study on the characteristics of Th1/Th2 immune response in cerebrospinal fluid of AIDS patients with cryptococcal meningitis.

Tytuł:: A preliminary study on the characteristics of Th1/Th2 immune response in cerebrospinal fluid of AIDS patients with cryptococcal meningitis.
Autorzy:: Li A; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Zhu W; Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Yin J; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Huang X; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Sun L; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Hua W; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Wang W; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Zhang T; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Dai L; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China. .
Wu H; Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China. .
Źródło:: BMC infectious diseases [BMC Infect Dis] 2021 May 29; Vol. 21 (1), pp. 500. Date of Electronic Publication: 2021 May 29.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central, [2001-
MeSH Terms:: Acquired Immunodeficiency Syndrome/*immunology
Cytokines/*cerebrospinal fluid
Meningitis, Cryptococcal/*cerebrospinal fluid
Meningitis, Cryptococcal/*immunology
Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/microbiology ; Adult ; Comorbidity ; Cryptococcus ; Cytokines/immunology ; Female ; Humans ; Immunity, Cellular ; Male ; Meningitis, Cryptococcal/complications ; Middle Aged ; Prospective Studies ; Th1-Th2 Balance ; Vascular Endothelial Growth Factor A
References:: PLoS Pathog. 2015 Apr 08;11(4):e1004754. (PMID: 25853653)
J Infect Dis. 2013 Jun 15;207(12):1817-28. (PMID: 23493728)
PLoS Med. 2010 Dec 21;7(12):e1000384. (PMID: 21253011)
Front Immunol. 2012 Jun 13;3:156. (PMID: 22707953)
PLoS Pathog. 2017 Mar 23;13(3):e1006207. (PMID: 28334020)
Sci Rep. 2016 Nov 10;6:36234. (PMID: 27830756)
Arthritis Rheumatol. 2014 May;66(5):1340-51. (PMID: 24470407)
Mem Inst Oswaldo Cruz. 2018;113(7):e170391. (PMID: 29513785)
Annu Rev Immunol. 2009;27:485-517. (PMID: 19132915)
mBio. 2017 Dec 12;8(6):. (PMID: 29233901)
Lupus. 2016 Aug;25(9):997-1003. (PMID: 26846690)
Trends Immunol. 2014 Oct;35(10):483-94. (PMID: 25182198)
Nat Rev Immunol. 2011 Apr;11(4):275-88. (PMID: 21394104)
Lancet Infect Dis. 2013 Jul;13(7):629-37. (PMID: 23735626)
mBio. 2017 Nov 21;8(6):. (PMID: 29162707)
Int Immunol. 2013 Aug;25(8):459-70. (PMID: 23532373)
AIDS Res Hum Retroviruses. 2014 Dec;30(12):1197-202. (PMID: 25131160)
Nat Rev Neurol. 2017 Jan;13(1):13-24. (PMID: 27886201)
N Engl J Med. 2020 Dec 3;383(23):2255-2273. (PMID: 33264547)
AIDS. 2016 Jan 28;30(3):395-404. (PMID: 26765934)
J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):299-307. (PMID: 28346317)
PLoS One. 2015 Mar 23;10(3):e0120297. (PMID: 25799044)
Infect Dis Poverty. 2018 Mar 24;7(1):25. (PMID: 29587840)
Curr Opin Infect Dis. 2016 Feb;29(1):10-22. (PMID: 26658650)
PLoS One. 2017 May 9;12(5):e0176304. (PMID: 28486489)
Am J Pathol. 2009 Feb;174(2):486-96. (PMID: 19147811)
Future Microbiol. 2012 Nov;7(11):1297-313. (PMID: 23075448)
Lancet Infect Dis. 2017 Aug;17(8):790-791. (PMID: 28483416)
Circulation. 2018 Mar 20;137(12):e67-e492. (PMID: 29386200)
Eur J Clin Microbiol Infect Dis. 2011 Dec;30(12):1483-7. (PMID: 21487762)
Arthritis Rheumatol. 2017 Jun;69(6):1325-1336. (PMID: 28118536)
AIDS Res Hum Retroviruses. 2020 Jun;36(6):490-500. (PMID: 31914800)
Immunology. 2009 Feb;126(2):177-85. (PMID: 19125888)
Infect Immun. 2014 Mar;82(3):937-48. (PMID: 24324191)
Lancet Infect Dis. 2017 Aug;17(8):873-881. (PMID: 28483415)
AIDS. 2016 Jan;30(2):193-201. (PMID: 26558730)
Infect Immun. 2007 Mar;75(3):1453-62. (PMID: 17210668)
Future Microbiol. 2015;10(4):565-81. (PMID: 25865194)
Zhonghua Nei Ke Za Zhi. 2018 Dec 1;57(12):867-884. (PMID: 30486555)
PLoS One. 2009 Sep 03;4(9):e6854. (PMID: 19727388)
J Int AIDS Soc. 2014 Oct 10;17:19184. (PMID: 25308903)
Mediators Inflamm. 2019 Dec 31;2019:2053958. (PMID: 32082071)
Clin Microbiol Infect. 2012 Feb;18(2):126-33. (PMID: 22264261)
PLoS One. 2015 Dec 04;10(12):e0144427. (PMID: 26637129)
Nat Rev Immunol. 2017 Feb;17(2):83-96. (PMID: 28044057)
Science. 2012 Feb 24;335(6071):936-41. (PMID: 22363001)
Grant Information:: YNKTTS20180107 China Primary Health Care Foundation; 2017ZX10201101 National Science and Technology Major Project of China; 81701984 National Natural Science Foundation of China; 2020A35 Beijing Talent Project in the New Millennium
Contributed Indexing:: Keywords: Acquired immunodeficiency syndrome; Cerebrospinal fluid; Cryptococcal meningitis; Cryptococcus; Cytokines
Substance Nomenclature:: 0 (Cytokines)
0 (Vascular Endothelial Growth Factor A)
Entry Date(s):: Date Created: 20210530 Date Completed: 20210609 Latest Revision: 20210609
Update Code:: 20240105
PubMed Central ID:: PMC8164222
DOI:: 10.1186/s12879-021-06138-z
PMID:: 34051748
: Czasopismo naukowe

Pełny tekst

Background: Cryptococcal Meningitis (CM) is a common opportunistic infection in the late stage of acquired immunodeficiency syndrome (AIDS). Despite the wide use of effective antiretroviral and antifungal therapy in AIDS patients, CM is still a major morbidity and mortality cause. Understanding the immune response in cryptococcal infection may help to improve the treatment strategies.
Methods: We established a prospective cohort of twelve AIDS patients with CM (HIV + CM+) admitted to the hospital from 2019 to 2020. All patients were examined at the baseline, 2 weeks, and 4 weeks thereafter. The level of 19 cytokines in cerebrospinal fluid (CSF) were recorded to analyze the characteristics and dynamic changes of Th1/Th2 immune response. Meanwhile, six AIDS patients without CM (HIV + CM-) and seventeen healthy subjects (HIV-CM-) were included as control groups for CSF assessment.
Results: The HIV+ CM+ group had higher CSF IFN-γ, TNF-α, IL-6, IL-7, IL-8, IL-10, IL-12 (P40), IL-15, IL-18, CCL2 levels but lower IL-4 when compared with the HIV-CM- group at baseline. And they also had a higher level of IL-12 (P40) and IL-17A compared with HIV + CM- patients. Except one patient dropped out of the study, eleven HIV + CM+ patients received induction antifungal therapy and regular CSF testing, and the mortality rate was 9.1% (1/11) and 18.2% (2/11) respectively at week 2 and week 4. Compared with baseline CSF cytokines, IL-2, IL-13, IL-17A, and VEGF-A decreased in week 2, and the VEGF-A levels further decreased in week 4. But there was no difference in the levels of all cytokines between survivors and the dead.
Conclusion: No evidence of Th1/Th2 imbalance was found in AIDS patients with CM. However, the CSF cytokine network may provide new clues for the treatment of AIDS patients with CM.
Trial Registration: This trial was prospectively registered in 2019.7.16. The registered number is ChiCTR1900024565 .

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja