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Tytuł:
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Regular aerobic exercise activates PDGF-BB/PDGFR-β signaling and modulates the inflammatory-anti-inflammatory balance in diet-induced obese mice.
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Autorzy:
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Wang X; Department of College of P.E and Sport, Beijing Normal University, Beijing, PR China. Electronic address: .
Yi X; Department of Kinesiology, Shenyang Sport University, Shenyang, Liaoning, PR China.
Tang D; Department of College of P.E and Sport, Beijing Normal University, Beijing, PR China. Electronic address: .
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Źródło:
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Obesity research & clinical practice [Obes Res Clin Pract] 2021 Jul-Aug; Vol. 15 (4), pp. 387-394. Date of Electronic Publication: 2021 May 27.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier, 2007-
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MeSH Terms:
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Diet, High-Fat*/adverse effects
Phosphatidylinositol 3-Kinases*
Animals ; Anti-Inflammatory Agents ; Becaplermin ; Mice ; Mice, Inbred C57BL ; Mice, Obese
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Contributed Indexing:
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Keywords: Exercise; Heart; Inflammation; Obesity; PDGF-BB
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Substance Nomenclature:
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0 (Anti-Inflammatory Agents)
1B56C968OA (Becaplermin)
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Entry Date(s):
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Date Created: 20210530 Date Completed: 20210927 Latest Revision: 20210927
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Update Code:
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20240105
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DOI:
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10.1016/j.orcp.2021.04.003
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PMID:
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34052185
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Objective: Regular aerobic exercise induces cardioprotection by counteracting the obesity-associated inflammatory response, dyslipidemia. PDGF-BB/PDGFR-β signaling is established as a crucial mechanism of endothelial cell-cardiomyocyte communication and cardioprotection, but its physiological roles in response to obesity and regular aerobic exercise are unknown.
Methods: Thirty C57BL/6 mice were divided into three groups: a normal diet group, a high-fat diet group, and a high-fat diet plus aerobic exercise group. Glucose metabolic parameters, inflammation-related indicators, and blood lipids indicators were detected. In addition, gene expression levels of the inflammatory factors, PDGF-BB, PDGFR-β, PI3K, Akt, eNOS, and P53 in cardiac tissue were quantified. Morphological analysis was also used to quantify the magnitude of inflammation.
Results: High-fat diet (HFD) feeding resulted in adiposity, dyslipidemia, and low levels of cardioprotective factors such as APN and eNOS (P < 0.05), which were improved significantly by 8 weeks of aerobic exercise (P < 0.05). HFD feeding increased the gene expression levels of proinflammatory cytokines and decreased the gene expression levels of anti-inflammatory cytokines in cardiac tissue (P < 0.05), which was reversed by regular aerobic exercise (P < 0.05). In addition, HFD feeding suppressed the levels of the cardioprotective factors PDGF-BB and eNOS through PDGF-BB/PDGFR-β/PI3K/Akt/eNOS signaling in cardiac tissue, while regular aerobic exercise activated PDGF-BB/PDGFR-β/PI3K/Akt/eNOS signaling.
Conclusion: Regular aerobic exercise improved adiposity, dyslipidemia induced by HFD feeding. Regular aerobic exercise exerted a prominent role in modulating the inflammatory-anti-inflammatory balance and activating the levels of the cardioprotective factors eNOS and PDGF-BB through PDGF-BB/PDGFR-β signaling.
(Copyright © 2021. Published by Elsevier Ltd.)
