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Tytuł:
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Usefulness and problems of cytological examination by endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal lymphadenopathy: A retrospective single-centre study.
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Autorzy:
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Sandoh K; Department of Pathology and Clinical Laboratory, Kansai Medical University, Hirakata, Osaka 573-1010, Japan.
Ishida M; Department of Pathology and Clinical Laboratory, Kansai Medical University, Hirakata, Osaka 573-1010, Japan.
Okano K; Department of Pathology and Clinical Laboratory, Kansai Medical University, Hirakata, Osaka 573-1010, Japan.
Ito H; Department of Pathology and Clinical Laboratory, Kansai Medical University, Hirakata, Osaka 573-1010, Japan.
Tsuta K; Department of Pathology and Clinical Laboratory, Kansai Medical University, Hirakata, Osaka 573-1010, Japan.
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Źródło:
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Molecular and clinical oncology [Mol Clin Oncol] 2021 Jul; Vol. 15 (1), pp. 138. Date of Electronic Publication: 2021 May 19.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London, UK : Spandidos Publications UK Ltd
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References:
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Cytopathology. 2007 Feb;18(1):3-7. (PMID: 17250596)
Diagn Cytopathol. 2019 Sep;47(9):869-875. (PMID: 31199571)
Diagn Cytopathol. 2018 Oct;46(10):815-825. (PMID: 30195266)
J Bronchology Interv Pulmonol. 2017 Jan;24(1):48-58. (PMID: 27984385)
Cancer Cytopathol. 2014 Aug;122(8):561-76. (PMID: 24760496)
Chest. 2018 Aug;154(2):349-356. (PMID: 29453944)
Diagn Cytopathol. 2020 Apr;48(4):316-321. (PMID: 31883315)
Chest. 2014 Sep;146(3):547-556. (PMID: 24481031)
Endoscopy. 2015 Jun;47(6):545-59. (PMID: 26030890)
J Am Soc Cytopathol. 2014 Mar - Apr;3(2):79-85. (PMID: 31051705)
Diagn Cytopathol. 2019 May;47(5):367-373. (PMID: 30576096)
Cytopathology. 2014 Oct;25(5):322-9. (PMID: 24844295)
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Contributed Indexing:
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Keywords: cytology; endobronchial ultrasound-guided transbronchial needle aspiration; lung cancer; lymphadenopathy; mediastinal lymph node; sarcoidosis
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Entry Date(s):
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Date Created: 20210531 Latest Revision: 20210601
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Update Code:
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20240105
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PubMed Central ID:
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PMC8145344
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DOI:
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10.3892/mco.2021.2300
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PMID:
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34055353
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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and useful technique for sampling mediastinal lymph nodes. High sensitivity and specificity of EBUS-TBNA in staging lung cancer have been reported. However, few studies have addressed the results of EBUS-TBNA in the diagnosis of mediastinal lymphadenopathy with or without lung cancer, since various neoplastic and non-neoplastic conditions can involve the mediastinal lymph nodes. The present study analysed the results of the cytological examination of mediastinal lymphadenopathy using EBUS-TBNA in Kansai Medical University Hospital (Hirakata, Japan). A total of 41 consecutive patients with mediastinal lymphadenopathy who underwent EBUS-TBNA between January 2008 and December 2019 in Kansai Medical University Hospital were enrolled. This cohort included 29 males and 12 females. Cytological analyses demonstrated that 16/17 (94.1%) patients with metastatic carcinoma were diagnosed as having carcinoma (malignancy). The sensitivity, specificity and positive predictive value of the cytological examination in cases of carcinoma were 94.1, 100 and 100, respectively. However, only 3/11 (27.3%) patients with sarcoidosis were diagnosed by cytological examination. The present study demonstrated that EBUS-TBNA may be a useful method for detecting metastatic carcinoma in the mediastinal lymph nodes. However, the detection rate of epithelioid granuloma, which is a characteristic feature of sarcoidosis, was low in the present cohort. Hence, an improvement in the sampling technique is necessary.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © Sandoh et al.)
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