Effect of Vitamin K-Mediated PXR Activation on Drug-Metabolizing Gene Expression in Human Intestinal Carcinoma LS180 Cell Line.

Szczegóły
Abstrakt

Tytuł:: Effect of Vitamin K-Mediated PXR Activation on Drug-Metabolizing Gene Expression in Human Intestinal Carcinoma LS180 Cell Line.
Autorzy:: Sultana H; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Kato A; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Ohashi A; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Takashima R; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Katsurai T; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Sato S; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Monma M; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Ohsaki Y; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.; International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Goto T; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Komai M; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Shirakawa H; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.; International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Źródło:: Nutrients [Nutrients] 2021 May 18; Vol. 13 (5). Date of Electronic Publication: 2021 May 18.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI Publishing
MeSH Terms:: Cytochrome P-450 CYP3A/*drug effects
Gene Expression/*drug effects
Pregnane X Receptor/*drug effects
Vitamin K/*pharmacology
ATP Binding Cassette Transporter, Subfamily B/drug effects ; Carcinoma/drug therapy ; Carcinoma/metabolism ; Cell Line, Tumor ; Humans ; Intestinal Neoplasms/drug therapy ; Intestinal Neoplasms/metabolism ; Nutritional Physiological Phenomena/genetics ; Rifampin/administration & dosage ; Vitamin K 1/pharmacology ; Vitamin K 2/analogs & derivatives ; Vitamin K 2/pharmacology
References:: Biochemistry. 2003 Feb 18;42(6):1430-8. (PMID: 12578355)
J Med Chem. 2011 Jul 14;54(13):4918-22. (PMID: 21618996)
Ann Nutr Metab. 2012;61(3):213-8. (PMID: 23183291)
J Pharm Pharmacol. 2009 May;61(5):541-58. (PMID: 19405992)
J Biol Chem. 2003 Nov 7;278(45):43919-27. (PMID: 12920130)
Mol Endocrinol. 2005 May;19(5):1170-80. (PMID: 15650019)
Clin Pharmacol Ther. 2007 May;81(5):669-78. (PMID: 17392718)
Drug Metab Dispos. 2006 Sep;34(9):1468-79. (PMID: 16751264)
Int J Mol Sci. 2019 Jun 11;20(11):. (PMID: 31212662)
J Biol Chem. 2006 Jul 14;281(28):19081-91. (PMID: 16682417)
J Nutr Biochem. 2010 Nov;21(11):1120-6. (PMID: 20149620)
Nat Med. 2001 May;7(5):584-90. (PMID: 11329060)
J Biol Chem. 2001 May 4;276(18):14581-7. (PMID: 11297522)
J Clin Invest. 1999 Jul;104(2):147-53. (PMID: 10411543)
Drug Metab Dispos. 2008 Jun;36(6):1172-80. (PMID: 18332086)
Mol Endocrinol. 2005 May;19(5):1125-34. (PMID: 15705662)
J Nutr. 2011 Feb;141(2):261-6. (PMID: 21178089)
Asia Pac J Clin Nutr. 2008;17(2):280-4. (PMID: 18586649)
Biosci Biotechnol Biochem. 2006 Apr;70(4):926-32. (PMID: 16636460)
J Clin Invest. 1998 Sep 1;102(5):1016-23. (PMID: 9727070)
Genes Dev. 1998 Oct 15;12(20):3195-205. (PMID: 9784494)
J Mol Biol. 2003 Aug 22;331(4):815-28. (PMID: 12909012)
Nucl Recept Signal. 2009;7:e001. (PMID: 19240808)
PLoS One. 2020 Mar 9;15(3):e0229769. (PMID: 32150581)
Clin Pharmacol Ther. 2004 Mar;75(3):172-83. (PMID: 15001968)
Annu Rev Pharmacol Toxicol. 1999;39:1-17. (PMID: 10331074)
In Vitro. 1976 Mar;12(3):180-91. (PMID: 1262041)
Nutrients. 2017 Nov 15;9(11):. (PMID: 29140269)
J Lipid Res. 2002 Mar;43(3):359-64. (PMID: 11893771)
Altern Med Rev. 2003 Aug;8(3):303-18. (PMID: 12946240)
J Biol Chem. 2006 Jun 23;281(25):16927-16934. (PMID: 16606623)
Clin Pharmacol Ther. 2000 Dec;68(6):598-604. (PMID: 11180019)
Nutrients. 2018 Jul 27;10(8):. (PMID: 30060524)
J Med Chem. 2012 Feb 23;55(4):1553-8. (PMID: 22250752)
Science. 2001 Jun 22;292(5525):2329-33. (PMID: 11408620)
Diabetes Care. 2010 Aug;33(8):1699-705. (PMID: 20424220)
Drug Metab Dispos. 1999 Jul;27(7):804-9. (PMID: 10383924)
J Med Chem. 2011 Jun 23;54(12):4269-73. (PMID: 21561094)
Endocr J. 2009;56(7):843-9. (PMID: 19550077)
Nutrients. 2018 Aug 28;10(9):. (PMID: 30154316)
Hepatology. 2015 Jul;62(1):265-78. (PMID: 25808545)
Front Pharmacol. 2016 Nov 25;7:456. (PMID: 27932985)
Biol Pharm Bull. 2018;41(6):972-977. (PMID: 29863087)
Drug Metab Dispos. 2004 Oct;32(10):1075-82. (PMID: 15269186)
J Pharm Pharmacol. 2003 Jan;55(1):59-66. (PMID: 12625868)
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12208-13. (PMID: 9770465)
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74. (PMID: 11248085)
Annu Rev Nutr. 1995;15:399-417. (PMID: 8527227)
Lancet. 1999 Dec 11;354(9195):2014-6. (PMID: 10636361)
Drug Metab Dispos. 2006 Nov;34(11):1863-7. (PMID: 16928788)
Cell. 1998 Jan 9;92(1):73-82. (PMID: 9489701)
Lipids Health Dis. 2011 Sep 13;10:158. (PMID: 21914161)
Grant Information:: A Grant-in-Aid for Scientific Research #23380070 Japan Society for the Promotion of Science; A Grant-in-Aid for Scientific Research #17H0314 Japan Society for the Promotion of Science; A Grant-in-Aid for Scientific Research #20H02928 Japan Society for the Promotion of Science; The JSPS Core-to-Core Program A (Advanced Research Network) entitled: "Establishment of in-ternational agricultural immunology research-core for quantum improvement in food safety" Japan Society for the Promotion of Science
Contributed Indexing:: Keywords: drug–nutrient interaction; isoprenoids; pregnane X receptor; vitamin K
Substance Nomenclature:: 0 (ABCB1 protein, human)
0 (ATP Binding Cassette Transporter, Subfamily B)
0 (Pregnane X Receptor)
11032-49-8 (Vitamin K 2)
12001-79-5 (Vitamin K)
27Y876D139 (menatetrenone)
84-80-0 (Vitamin K 1)
EC 1.14.14.1 (Cytochrome P-450 CYP3A)
EC 1.14.14.55 (CYP3A4 protein, human)
VJT6J7R4TR (Rifampin)
Entry Date(s):: Date Created: 20210602 Date Completed: 20210723 Latest Revision: 20210723
Update Code:: 20240104
PubMed Central ID:: PMC8157877
DOI:: 10.3390/nu13051709
PMID:: 34069974
: Czasopismo naukowe

Full Text Finder

The pregnane X receptor (PXR) is the key regulator of our defense mechanism against foreign substances such as drugs, dietary nutrients, or environmental pollutants. Because of increased health consciousness, the use of dietary supplements has gradually increased, and most of them can activate PXR. Therefore, an analysis of the interaction between drugs and nutrients is important because altered levels of drug-metabolizing enzymes or transporters can remarkably affect the efficiency of a co-administered drug. In the present study, we analyzed the effect of vitamin K-mediated PXR activation on drug metabolism-related gene expression in intestine-derived LS180 cells via gene expression studies and western blotting analyses. We demonstrated that menaquinone 4 (MK-4), along with other vitamin Ks, including vitamin K 1 , has the potential to induce MDR1 and CYP3A4 gene expression. We showed that PXR knockdown reversed MK-4-mediated stimulation of these genes, indicating the involvement of PXR in this effect. In addition, we showed that the expression of MDR1 and CYP3A4 genes increased synergistically after 24 h of rifampicin and MK-4 co-treatment. Our study thus elucidates the importance of drug-nutrient interaction mediated via PXR.

Informacja