Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion.

Tytuł:: Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion.
Autorzy:: Sevillano J; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
Sánchez-Alonso MG; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
Pizarro-Delgado J; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
Ramos-Álvarez MDP; Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 May 28; Vol. 22 (11). Date of Electronic Publication: 2021 May 28.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Diabetes Mellitus, Type 2/*physiopathology
Insulin/*metabolism
Receptor-Like Protein Tyrosine Phosphatases, Class 2/*metabolism
Animals ; Humans ; Insulin Resistance ; Obesity ; Prevalence ; Protein Tyrosine Phosphatases/metabolism ; Receptor, Insulin/metabolism ; Signal Transduction/physiology
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Grant Information:: RTI2018-095615-B-I00 Ministerio de Ciencia, Innovación y Universidades of Spain; B2017/BMD- 3684 Comunidad de Madrid
Contributed Indexing:: Keywords: T2DM; insulin secretion; insulin signaling; receptor protein tyrosine phosphatases (RPTP)
Substance Nomenclature:: 0 (Insulin)
EC 2.7.10.1 (Receptor, Insulin)
EC 3.1.3.48 (Protein Tyrosine Phosphatases)
EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 2)
Entry Date(s):: Date Created: 20210602 Date Completed: 20210615 Latest Revision: 20210615
Update Code:: 20240104
PubMed Central ID:: PMC8198922
DOI:: 10.3390/ijms22115812
PMID:: 34071721
: Czasopismo naukowe

Pełny tekst

Changes in lifestyle in developed countries have triggered the prevalence of obesity and type 2 diabetes mellitus (T2DM) in the latest years. Consequently, these metabolic diseases associated to insulin resistance, and the morbidity associated with them, accounts for enormous costs for the health systems. The best way to face this problem is to identify potential therapeutic targets and/or early biomarkers to help in the treatment and in the early detection. In the insulin receptor signaling cascade, the activities of protein tyrosine kinases and phosphatases are coordinated, thus, protein tyrosine kinases amplify the insulin signaling response, whereas phosphatases are required for the regulation of the rate and duration of that response. The focus of this review is to summarize the impact of transmembrane receptor protein tyrosine phosphatase (RPTPs) in the insulin signaling cascade and secretion, and their implication in metabolic diseases such as obesity and T2DM.

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