Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015-2017 Cohort from Tashkent, Uzbekistan.

Szczegóły
Abstrakt

Tytuł:: Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015-2017 Cohort from Tashkent, Uzbekistan.
Autorzy:: Sadirova D; Center of Phthisiology and Pulmonology of Tashkent City, Tashkent 100043, Uzbekistan.
Grigoryan R; TB Research and Prevention Center, Yerevan 0023, Armenia.
Parpieva N; Republican Specialized Scientific Practical Medical Center of Phthisiology and Pulmonology, Tashkent 100043, Uzbekistan.
Barotova V; Tashkent City AIDS Center, Tashkent 100043, Uzbekistan.
Trubnikov A; Center of Phthisiology and Pulmonology of Tashkent City, Tashkent 100043, Uzbekistan.
Kalandarova L; Center of Phthisiology and Pulmonology of Tashkent City, Tashkent 100043, Uzbekistan.
Gadoev J; World Health Organization (WHO) Country Office in Uzbekistan, 16 Tarobiy Street, Tashkent 100100, Uzbekistan.
Mukhtarov D; Tashkent Institute of Postgraduate Medical Education, Tashkent 100043, Uzbekistan.
Buziashvili M; National Center for Tuberculosis and Lung Diseases, Tbilisi 01790101, Georgia.
Tukvadze N; National Center for Tuberculosis and Lung Diseases, Tbilisi 01790101, Georgia.
Hovhannesyan A; World Health Organization, Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark.
Dadu A; World Health Organization, Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark.
Źródło:: International journal of environmental research and public health [Int J Environ Res Public Health] 2021 May 27; Vol. 18 (11). Date of Electronic Publication: 2021 May 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Basel : MDPI, c2004-
MeSH Terms:: HIV Infections*/complications
HIV Infections*/drug therapy
HIV Infections*/epidemiology
Tuberculosis*/epidemiology
Adolescent ; CD4 Lymphocyte Count ; Cohort Studies ; Humans ; Incidence ; Retrospective Studies ; Risk Factors ; Uzbekistan/epidemiology
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Grant Information:: 001 International WHO_ World Health Organization; D43 TW007124 United States TW FIC NIH HHS
Contributed Indexing:: Keywords: Central Asia; HIV; SORT IT; Uzbekistan; incidence rates; operational research; tuberculosis
Entry Date(s):: Date Created: 20210602 Date Completed: 20210701 Latest Revision: 20220716
Update Code:: 20240104
PubMed Central ID:: PMC8199393
DOI:: 10.3390/ijerph18115746
PMID:: 34071899
: Czasopismo naukowe

People living with the human immunodeficiency virus (PLHIV) have a higher risk of developing active tuberculosis (TB) disease, and TB remains a major cause of death in PLHIV. Uzbekistan is facing a substantial TB epidemic, which increases the risk of PLHIV developing active TB. Our retrospective cohort study aimed to evaluate the incidence rate and assess the risk factors for developing active TB among PLHIV. We collected secondary data extracted from medical charts of all patients, newly diagnosed at the AIDS Center in Tashkent, during the period of 2015-2017. The incidence rate of TB among PLHIV was 5.1 (95% CI: 4.5-6.0) per 1000 person/month. Adjusted regression analysis showed three major risk factors for TB, namely, being less than 15 years old (hazard ratio (HR) 5.83; 95% CI: 3.24-10.50, p value = 0.001),low CD4 count (adjusted hazard ratio(aHR) 21.0; 95% CI: 9.25-47.7, p value < 0.001), and antiretroviral therapy (ART) interruption/not receiving ART (aHR 5.57; 95% CI: 3.46-8.97 and aHR 6.2; 95% CI: 3.75-10.24, p value < 0.001, respectively) were significantly associated with developing active TB among PLHIV. Our findings indicate that taking prescribed ART without interruptions and maintaining CD4cell counts higher than 320 cells/μL are essential to prevent the development of active TB among PLHIV.

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