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Tytuł:
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Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing.
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Autorzy:
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Kaczmarek-Szczepańska B; Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toruń, Poland.
Ostrowska J; Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toruń, Poland.
Kozłowska J; Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toruń, Poland.
Szota Z; Department of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, 87-100 Toruń, Poland.
Brożyna AA; Department of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, 87-100 Toruń, Poland.
Dreier R; Institute of Physiological Chemistry and Pathobiochemistry, Waldeyerstraße 15, 48149 Münster, Germany.
Reiter RJ; Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA.
Slominski AT; Comprehensive Cancer Center, Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, AL 35294, USA.
Steinbrink K; Department of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.
Kleszczyński K; Department of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.
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Źródło:
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International journal of molecular sciences [Int J Mol Sci] 2021 May 26; Vol. 22 (11). Date of Electronic Publication: 2021 May 26.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI, [2000-
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MeSH Terms:
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Bandages*
Melatonin*/chemistry
Melatonin*/pharmacokinetics
Melatonin*/pharmacology
Chitosan/*chemistry
Collagen/*chemistry
Dermis/*metabolism
Epidermis/*metabolism
Fibroblasts/*metabolism
Keratinocytes/*metabolism
Cell Line ; Dermis/pathology ; Drug Evaluation, Preclinical ; Epidermis/pathology ; Fibroblasts/pathology ; Humans ; Keratinocytes/pathology
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References:
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Grant Information:
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KL2900/2-1 Deutsche Forschungsgemeinschaft; 282/2021 IDUB SD Nicoluas Copernicus University in Torun
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Contributed Indexing:
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Keywords: biopolymers; chitosan; collagen; cutaneous cells; melatonin; scaffolds; wound healing
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Substance Nomenclature:
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9007-34-5 (Collagen)
9012-76-4 (Chitosan)
JL5DK93RCL (Melatonin)
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Entry Date(s):
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Date Created: 20210602 Date Completed: 20210617 Latest Revision: 20210617
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Update Code:
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20240104
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PubMed Central ID:
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PMC8197906
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DOI:
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10.3390/ijms22115658
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PMID:
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34073402
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The development of scaffolds mimicking the extracellular matrix containing bioactive substances has great potential in tissue engineering and wound healing applications. This study investigates melatonin-a methoxyindole present in almost all biological systems. Melatonin is a bioregulator in terms of its potential clinical importance for future therapies of cutaneous diseases. Mammalian skin is not only a prominent melatonin target, but also produces and rapidly metabolizes the multifunctional methoxyindole to biologically active metabolites. In our methodology, chitosan/collagen (CTS/Coll)-contained biomaterials are blended with melatonin at different doses to fabricate biomimetic hybrid scaffolds. We use rat tail tendon- and Salmo salar fish skin-derived collagens to assess biophysical and cellular properties by ( i ) Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), ( ii ) thermogravimetric analysis (TG), ( iii ) scanning electron microscope (SEM), and ( iv ) proliferation ratio of cutaneous cells in vitro. Our results indicate that melatonin itself does not negatively affect biophysical properties of melatonin-immobilized hybrid scaffolds, but it induces a pronounced elevation of cell viability within human epidermal keratinocytes (NHEK), dermal fibroblasts (NHDF), and reference melanoma cells. These results demonstrate that this indoleamine accelerates re-epithelialization. This delivery is a promising technique for additional explorations in future dermatotherapy and protective skin medicine.
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